Renal length in sickle cell disease: observation from a cohort study
Clin Nephrol
; 46(6): 384-8, Dec. 1996.
Artigo
em Inglês
| MedCarib
| ID: med-2052
Biblioteca responsável:
JM3.1
Localização: JM3.1; RC902.A1C4
ABSTRACT
Renal length has been measured by ultrasound in 237 subjects with homozygous sickle cell (SS) disease, 147 with sickle cell-hemoglobin C (SC) disease, and in 78 age-matched controls with a normal hemoglobin (AA) genotype. As expected, renal length increased with age in all genotypes but mean length was significantly greater in SS disease compared with SC disease (mean difference 4.3 mm after adjustment for height) and significantly greater in both genotypes than in AA controls (SS/AA difference 9.2 mm, SC/AA difference 5.0 mm after adjustment for height). Examination of relationship between renal length and some hematological indices (hemoglobin, fetal hemoglobin, reticulocyte counts, alpha thalassemia status) in SS or SC disease showed only a significant negative correlation with hemoglobin and positive correlation with reticulocyte count in SS disease. Further analysis suggested that the stronger relationship was between renal length and high reticulocyte count. The mechanism of renal enlargement is unknown although glomerular hypertrophy and increase renal blood volume are likely contributors.(AU)
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Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Doença da Hemoglobina SC
/
Anemia Falciforme
/
Rim
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin Nephrol
Ano de publicação:
1996
Tipo de documento:
Artigo