Activated protein C resistance in homozygous sickle cell disease
Br J Haematol
; 96(4): 854-6, Mar.1997.
Artigo
em Inglês
| MedCarib
| ID: med-2053
Biblioteca responsável:
JM3.1
Localização: JM3.1; RB145.A1B7
ABSTRACT
The activated protein C resistance (APC-R) ratios in 50 patients with steady state homozygous sickle cell (SS) disease and 59 healthy AA controls was measured. There was a significant reduction in median APC-R ratio in sickle cell disease compared to controls. This reduction in APC-R ratio was not explained by (1) the presence of the factor V Leiden, found in only one of 165 patients with SS disease including those tested for APC-R, or (2) the presence of lupus anticoagulants. However, the raised levels of factor VIIIC in SS patients in this study may be contributing to the increased resistance to APC, which in turn may contribute to the vaso-occlusive complication of SS disease.(AU)
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Base de dados:
MedCarib
Assunto principal:
Transtornos das Proteínas Sanguíneas
/
Proteína C
/
Anemia Falciforme
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Br J Haematol
Ano de publicação:
1997
Tipo de documento:
Artigo