Identification of human T-cell leukemia/lymphoma virus type I antibodies, DNA, and protein in patients with polymyositis
Arthritis Rheum
; 38(5): 690-8, May 1995.
Artigo
em Inglês
| MedCarib
| ID: med-2077
Biblioteca responsável:
JM3.1
Localização: JM3.1; RC925.A1A7
ABSTRACT
OBJECTIVE:
To investigate a possible association between human T cell leukemia/lymphoma virus type I (HTLV-I) and polymyositis (PM).METHODS:
Sera and muscle biopsy samples from 9 Jamaican PM patients were compared with specimens from American HTLV-I positive PM patients and normal controls. Sera were evaluated for HTLV antibodies by enzyme-linked immunosorbent assay and Western blot. The biopsy samples were analyzed for HTLV-I/II DNA by polymerase chain reaction and were also immunohistochemically stained for HTLV gp46 envelope protein.RESULTS:
Seven of the 8 Jamaican PM patients from whom sera were available were HTLV-I seropositive. The muscle biopsies of all 9 Jamaican patients demonstrated severe lymphocytic infiltration, cellular degeneration, myofiber atrophy, and fibrosis. Each muscle biopsy specimen contained HTLV-I DNA. Two of 6 samples demonstrated intense staining for HTLV-I gp46 in many of the invading mononuclear cells and weak staining for HTLV-I gp46 in many of the other specimens were weakly positive for gp46 in rare mononuclear cells. All controls specimens were negative for the presence of HTLV-I DNA and protein.CONClUSION:
HTLV-I is associated with an inflammatory muscle disease characterized by direct invasion of the affected muscle by HTLV-I-infected mononuclear cells.(AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
DNA Viral
/
Anticorpos Anti-HTLV-I
/
Produtos do Gene env
/
Proteínas Oncogênicas de Retroviridae
/
Polimiosite
Tipo de estudo:
Estudo diagnóstico
Limite:
Adulto
Idioma:
Inglês
Revista:
Arthritis Rheum
Ano de publicação:
1995
Tipo de documento:
Artigo