Human T-lymphotropic virus type I DNA in spinal cord of tropical spastic paraparesis with concomitant human T-lymphotropic virus type I negative Hodgkin's disease
Hum Pathol
; 25(10): 1101-6, Oct. 1994.
Artigo
em Inglês
| MedCarib
| ID: med-2085
Biblioteca responsável:
JM3.1
Localização: JM3.1; RB1.H8
ABSTRACT
We studied a 58 year old black women from Barbados who simultaneously developed myelopathy and lymphoma with human T-lymphotropic virus type I (HTLV-I) antibodies in serum and cerebrospinal fluid and died 3 years after onset. Neuropathological examination showed typical tropical spastic paraparesis (TSP). The polymerase chain reaction (PCR) demonstrated defective proviral genome retaining the HTLV-I pX and env regions in thoracic spinal cord, the level most severely affected. Defective HTLV-I in the nervous system retaining the pX region may be relevant to pathogenesis because circulating CD8+ cytotoxic lymphocytes specific for HTLV-I pX occur in HTLV-I myelopathy. This patient's lymph node biopsy specimen was consistent with Hodgkin's disease (HD), nodular sclerosis subtype, of B-cell origin. The PCR in the paraffin-embedded lymph node involved by HD failed to amplify HTLV-I proviral sequences. Complete HTLV-I proviral amplification was obtained in paraffin-embedded lymph node form positive controls (adults T-cells leukemia). To our knowledge the association of TSP and HD has not been reported previously. Despite claims the HD may be associated with HTLV-I, we demonstrated absence of HTLV-I infected T-cell in the lymphoid infiltrate of HD in this case, positive HTLV-I serology notwithstanding.(AU)
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Base de dados:
MedCarib
Assunto principal:
Medula Espinal
/
Doença de Hodgkin
/
Vírus Linfotrópico T Tipo 1 Humano
/
Paraparesia Espástica Tropical
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Hum Pathol
Ano de publicação:
1994
Tipo de documento:
Artigo