The effect of splenectomy for hypersplenism on whole body protein turnover, resting metabolic rate and growth in sickle cell disease
Eur J Clin Nutr
; 50(10): 672-5, Oct. 1996.
Artigo
em Inglês
| MedCarib
| ID: med-2134
Biblioteca responsável:
JM3.1
Localização: JM3.1
ABSTRACT
OBJECTIVE:
To determine whether, in the same individual, an observed fall in whole body protein turnover following splenectomy in children with hypersplenism and homozygous sickle cell (SS) disease is associated with a measurable fall in resting metabolic rate (RMR) and an increase in rate of growth.SUBJECTS:
Six children (5 SS disease, 1 S beta degree thalassaemia), aged 68 to 126 months, were studied before and after splenectomy for hypersplenism.DESIGN:
Protein turnover was measured by the end product method using prime/intermittent oral doses of 15N-glycine and RMR by indirect calorimetry before preoperative transfusion and repeated at least eight weeks after splenectomy. Height and weight velocities were measured over six month periods before and after splenectomy.SETTING:
University Hospital of the West Indies in Jamaica and the Medical Research Laboratories (Jamaica).RESULTS:
After splenectomy protein turnover fell significantly by 30 percent and RMR by 34 kJ/kg/d. Mean weight velocity which was below normal before surgery, z = -2.3, improved significantly after surgery, z = 0.7, (p = 0.03). Height velocity increase in two children but the mean height velocity did not change following splenectomy. The reduction in protein turnover was estimated to account for 62 percent of the fall in RMR.CONCLUSION:
This study confirms that there is a significant reduction in energy expenditure following splenectomy for hypersplenism in SS disease. A reduction in protein turnover was a major contributor to the saving in energy, although it is not clear whether it accounted for all. In the present group of children the energy saved was associated with an improvement in the wasting present before splenectomy.(AU)
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Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Esplenectomia
/
Metabolismo Basal
/
Proteínas
/
Hiperesplenismo
/
Anemia Falciforme
Limite:
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Eur J Clin Nutr
Ano de publicação:
1996
Tipo de documento:
Artigo