Angiotensinogen and blood pressure among blacks: findings from a community survey in Jamaica
J Hypertens
; 14(3): 315-21, Mar. 1996.
Article
em En
| MedCarib
| ID: med-2993
Biblioteca responsável:
JM3.1
Localização: JM3.1; Reprint Collection
ABSTRACT
OBJECTIVE:
To examine the association between blood pressure, angiotensinogen levels, angiotensin converting enzyme activity and polymorphisms of the angiotensinogen and angiotensin converting enzyme genes in a population-based sample.METHOD:
Five hundred participants were recruited in a house-to-house survey of three communities in metropolitan areas of Kingston and St. Andrew, in Jamaica. Demographic data, anthropometric and blood pressure measurements were obtained for each participant during a brief clinic visit. Circulating levels of angiotensinogen and angiotensin converting enzyme genes were determined.RESULTS:
A weak association between angiotensinogen level, angiotensin converting enzyme activity and blood pressure was identified in this population, but substantial joint effect of angiotensin converting enzyme activity and agiotensinogen level on blood pressure was apparent. Variants of the angiotensinogen gene had inconsistent effects on blood pressure and on the risk of hypertension. Angiotensinogen level and angiotensin converting enzyme activity were significantly related to several measures of obesity, including body mass index, waist circumference and skin fold thickness.CONCLUSION:
The angiotensinogen and angiotensin converting enzyme genetic variants which were studied appear to have only a modest relationship with blood pressure and associated anthropometric risk factors among blacks. (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Angiotensina II
/
Angiotensinogênio
/
Pressão Arterial
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
País/Região como assunto:
Caribe ingles
/
Jamaica
Idioma:
En
Revista:
J Hypertens
Ano de publicação:
1996
Tipo de documento:
Article