The efficacy and acceptability of perindopril for the treatment of essential hypertension in a Caribbean population

ABSTRACT

This study aims at assessing the efficacy and acceptability of perindopril in a Caribbean population. 435 patients from the English speaking and Dutch Caribbean islands with essential hypertension with a diastolic BP between 95 and 125 mmHg. were enrolled into an open dose titration study of perindopril of 3 months duration. 95 percent of patients were controlled (diastolic BP <90 mmHg.) with perindopril in monotherapy; and an additional 7.81 percent were controlled with the addition of hydrochlorothiazide 25 mg. Control was similar in the black population with a mean supine blood pressure reduction of 23.1 mm Hg. systolic and 17.1 mmHg diastolic. Perindopril was well tolerated with a low reported incidence of cough. This study confirms the antihypertensive efficacy of perindopril in mild to moderate hypertension in the Caribbean population and more specifically in the Afro-Caribbean population, as well as its clinical and biological acceptability. (summary)