Failure of dexamphetamine to antagonise a cholinomimetic-induced hyperactivity
Neuropharmacology
; 15(5): 269-71, May 1976.
Artigo
em Inglês
| MedCarib
| ID: med-5354
Biblioteca responsável:
JM9.1
Localização: JM9.1; RM315.N4
ABSTRACT
Rats that were treated with physostigmine (0.05 mg/kg) manifested marked hyperactive behaviour. A subsequent injection of dexamphetamine (2.0 mg/kg) did not antagonise the physostigmine-induced locomotor hyperactivity, whereas atropine (10 mg/kg) attenuated the hyperactive behaviour. Higher doses of physostigmine depressed the locomotory behaviour of rats. Carbachol and (ñ)-O-methyl-p-tyrosine did not significantly affect rats' locomotory behaviour. Implications of the results are discussed in terms of the aetiology of hyperkinesia (AU)
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Base de dados:
MedCarib
Assunto principal:
Fisostigmina
/
Dextroanfetamina
/
Atividade Motora
Limite:
Animais
Idioma:
Inglês
Revista:
Neuropharmacology
Ano de publicação:
1976
Tipo de documento:
Artigo