Starvation reduces renal pyruvate dehydrogenase phosphate phosphatase activity - abstract

ABSTRACT

We have measured the rates of activation of the mitochondrial pyruvate dehydrogenase multi-enzyme complex (PHD) in kidney mitochondria from fed and starved rats. A significant diminution of rate due to starvation was found. The effect of varying Mgý+ concentration on the rate suggests that starvation induced a covalent modification of PDH phosphatase or its substrate which modification impaired dephosphorylation by decreasing its sensitivoty to Mgý+ (AU)