Control mechanisms in the synthesis of glucose - abstract

ABSTRACT

The synthesis of phosphoenol pyruvate, the first committed step in gluconeogenesis, was examined in guinea pig mitochondria. The effect of short and long chain fatty acids and ketone bodies on phosphoenal pyruvate synthesis from Krevs cycle intermediate was measured. Long chain fatty acids and acetoacetate increased phosphoenol pyruvate synthesis. Short chain fatty acids depressed the synthesis. Because the physiological level of long chain fatty acid and ketone bodies is increased in conditions of increased gluconeogenesis to wit, starvation and diabetes, a theory is put forward which seeks to explain how fatty acids and ketone bodies trigger off and control the increased glucose synthesis(AU)