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Preliminary report on clinical trials of hycanthone in s. mansoni infections - abstract
West Indian med. j ; 18(2): 128, June 1969.
Artigo em Inglês | MedCarib | ID: med-6412
Biblioteca responsável: JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
Hycanthone, a therapeutically active metabolite of lucanthone, was identified in 1965. In experimental schistosoma infections it was found to be three times as active as lucanthone in mice and ten times as active in hamsters. A single intramuscular dose was found to be as effective as a 5 day oral regimen. The present study was undertaken to evaluate the chemotherapeutic effect of hycanthone administered parenterally in patients infected with s. mansoni. All patients were admitted to the hospital ward for treatment. S.mansoni eggs in fecal specimens were counted by the filtration-staining technique. Three stool specimens were examined before treatment and at each follow-up visit. At the time of abstract preparation, sixty-one patients have been treated with intramuscular hycanthone at a dose level of 3mg/kg. Thirty-three (54 percent) of these had vomiting as the major side effect. Other side effects included anorexia, nausea and abdominal pain. For the most part side effects did not last beyond 24 hours. Thirty four patients have been seen at 6 weeks follow up examination. Seventeen (50 percent) have no eggs in three specimens. In those who are still excreting eggs, the average percent reduction in egg excretion is 97.92 percent. Of those not excreting eggs at six weeks eight (47 percent) had an initial egg count of less than 50 eggs/gm faeces; five (29.4 percent) of those still excreting eggs had initial egg counts of less than 50. The mean reduction in egg excretion for the entire group is 98.96 percent (AU)
Assuntos
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Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Negligenciadas Problema de saúde: Doenças Negligenciadas / Esquistossomose / Zoonoses Base de dados: MedCarib Assunto principal: Schistosoma mansoni / Hicantone Limite: Animais / Humanos Idioma: Inglês Revista: West Indian med. j Ano de publicação: 1969 Tipo de documento: Artigo / Congresso e conferência
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Coleções: Bases de dados internacionais Contexto em Saúde: Doenças Negligenciadas Problema de saúde: Doenças Negligenciadas / Esquistossomose / Zoonoses Base de dados: MedCarib Assunto principal: Schistosoma mansoni / Hicantone Limite: Animais / Humanos Idioma: Inglês Revista: West Indian med. j Ano de publicação: 1969 Tipo de documento: Artigo / Congresso e conferência
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