Immunological studies in infective dermatitis flow cytometric analysis of lymphocyte subpopulations in 41 cases - abstract
West Indian med. j
; 41(1): 33, Apr. 1992.
Article
em En
| MedCarib
| ID: med-6454
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
Infective dermatitis (ID) is a newly described HTLV-I associated with chronic dermatitis that is characterized by super infection of the skin with non-virulent pathogens. In order to investigate the possible mechanisms for this associated immune dysfunction we examined, by flow cytometry, lymphocyte subpopulations in a study group of 41 patients with infective dermatitis and compared the results with an age and sex matched group of patients with atopic eczema (AE) not associated with HTLV-I. Our results show an increase in total T-cells (CD3/Leu 4 +)2 T-helper inducer cells (CD4/Leu 3+), Activated T-cells (Leu RLA - DR+) and a subpopulation of cytotoxic T-cells (CD57 CD8/Leu 7+ Leu 2+) in the study group over the controls. The results support previous observations that T-cell aberrations in asymptomatic HTLV-I seropositive individuals, patients with Tropical Spastic Paraparesis (TSP) and adult T-cell leukaemia (ATL). It would appear that HTLV-I-induced immunodeficiency may be the result of phenotypic qualitative defects in T-lymphocyte subpopulations although absolute counts may be elevated (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Infecções por HTLV-I
/
Dermatite
Tipo de estudo:
Qualitative_research
Limite:
Humans
Idioma:
En
Revista:
West Indian med. j
Ano de publicação:
1992
Tipo de documento:
Article
/
Congress and conference