Screening of cord blood for haemoglobinopathies and thalassaemia by high-performance liquid chromatography - abstract
West Indian med. j
; 41(Suppl. 1): 26, Apr. 1992.
Artigo
em Inglês
| MedCarib
| ID: med-6466
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
A high-performance liquid chromatography (HPLC) method for the screening of haemoglobins in cord blood was evaluated and the gene frequencies of the structural haemoglobin variants HbS and HbC and the synthesis variants O- and á+ -thalassaemia were studied in babies born on the Caribbean island of Curacao, the Netherlands Antilles. In 3 months, 67.2 percent of all (748) newborns were screened and 122 (24.3 percent) had an abnormal haemoglobin pattern, of which 53 (43.4 percent) had a haemoglobinopathy (HbS or HbC), 64(52.2 percent) O-thalassaemia (Hb Barts > 0.5 percent, corresponding with heterozygous or homozygous O-thalassaemia-2) and 5 (4.1 percent) a haemoglobinopathy plus O-thalassaemia. None of the newborns with heterozygous HbS and HbC had concomitant á+-thalassaemia. The population genotype frequency of heterozygous O-thalassaemia -2 remain undetected. The data are in excellent agreement with comparable published results. The HPLC method proved pre-eminently suitable for the screening of cord blood samples. (AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Talassemia
/
Sangue Fetal
/
Hemoglobinopatias
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Limite:
Humanos
/
Recém-Nascido
País/Região como assunto:
Antilhas Neerlandesas
/
Caribe
/
Caribe Inglês
Idioma:
Inglês
Revista:
West Indian med. j
Ano de publicação:
1992
Tipo de documento:
Artigo
/
Congresso e conferência