Increasing the incidence of the Guillain-Barre syndrome in Curacao
West Indian med. j
; 49(Suppl 2): 42, Apr. 2000.
Article
em En
| MedCarib
| ID: med-941
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
OBJECTIVE:
To confirm an observed increase in the occurrence of Guillain-Barre syndrome (GBS) in patients in Curacao. DESIGN ANDMETHODS:
Between 1987 and 1999, medical records of all patients who fulfilled the National Institute of Neurological Communicative Disorders and Stroke (NINCDS) criteria for GBS were reviewed.RESULTS:
Forty-nine patients were diagnosed as GBS resulting in an incidence rate (IR) of 2.53/100,000 inhabitants (95 percent CI 1.87-3.35). From 1987 to 1991, the IR remained stable, whereas from 1992 to 1999, there was a linear increase in the IR. There was a high IR in the colder months and a low IR in the warmer months. Patients showed a low percentage of sensory involvement (17 percent, generally 65 percent), rapid progression of the disease (83 percent, generally 30 percent), high percentage of artificial respiration (31 percent, generally 17 percent) and high mortality rate (23 percent, generally 3-5 percent). Fifty-five percent of the patients reported a preceding gastroenteritis (GE); 9/10 serum samples showed evidence of a recent Campylobacter jejuni infection.CONCLUSIONS:
This is the first report of an increase in IR of GBS over a longer period, associated with low percentage of sensory involvement, a more severe course and a high mortality rate. The characteristics suggest a role for C jejuni. Prospective research is needed to show whether the increase in GBS is due to an overall increase in IR of C. jejuni infections on the island.(Au)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Polirradiculoneuropatia
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Antillas holandesas
/
Caribe
/
Caribe ingles
Idioma:
En
Revista:
West Indian med. j
Ano de publicação:
2000
Tipo de documento:
Article