Rate of expulsion of Trichuris trichiura with multiple and single dose regimens of albendazole
Trans R Soc trop Med Hyg
; 79(5): 641-4, 1985.
Artigo
em Inglês
| MedCarib
| ID: med-9462
Biblioteca responsável:
JM3.1
Localização: JM3.1; RC960.R6
ABSTRACT
The efficacy of multiple and single dose regimens of albendazole on Trichuris trichiura infection was evaluated by counting the number of worms expelled/day from two pair-matched groups of children, for nine days following therapy. The temporal patterns of worm expulsion were similar whether the children received a single 400 mg dose or two consecutive doses no worms were passed before the second day, or after the sixth day, after intervention, and the maximum worm expulsion rate was attained on the fourth day. A second treatment six days after the first expelled no more worms. The results obtained here resemble those obtained previously with a three-day (600 mg) regimen of mebendazole in a study of heavily infected children. We conclude that irrespective of dose, benzimidazole carbamates require the gut transit time plus 48 hours to immobilize T. trichiura; and that single dose of albendazole is effective against light infections of T. trichiura but requires further evaluation with high intensity infections.(AU)
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Coleções:
Bases de dados internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Helmintíase
/
Doenças Negligenciadas
/
Zoonoses
Base de dados:
MedCarib
Assunto principal:
Tricuríase
/
Benzimidazóis
/
Anti-Helmínticos
Limite:
Criança
/
Criança, pré-escolar
/
Humanos
Idioma:
Inglês
Revista:
Trans R Soc trop Med Hyg
Ano de publicação:
1985
Tipo de documento:
Artigo