Deficiency of factor B of the complement system in sickle cell anaemia
Br Med J
; 1(6006): 367-9, Feb. 14, 1976.
Artigo
em Inglês
| MedCarib
| ID: med-9574
Biblioteca responsável:
JM3.1
Localização: JM3.1; R31.B75
ABSTRACT
Factors B and D as well as the total activity of the alternative pathway of complement activation were measured using a functional assay in sera from 29 patients with sickle cell anaemia and 18 normal controls. Total alternative pathway activity was reduced in the patients compared with controls. In patients with abnormally low total alternative pathway activity factor D levels were normal, whereas factor B levels were significantly depresed to a mean level of about half of normal. Regression analysis in patients also showed a singnificant relation between total alternative pathway activity and factor B levels. A deficiency of factor B is the likely cause of the defect in the complement system in patients with sickle cell anaemia. Such a defect may contribute to the excessive proneness of such patients to severe infection.(AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Proteínas do Sistema Complemento
/
Complemento C3
/
Glicoproteínas
/
Precursores Enzimáticos
/
Globulinas
/
Anemia Falciforme
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Br Med J
Ano de publicação:
1976
Tipo de documento:
Artigo