Adverse reactions after large-scale treatment of onchocerciasis with ivermectin: combined results from eight community trials
Bulletin of the World Health Organization (WHO)
; 67(6): 707-19, 1989. ilus
Artigo
em Inglês
| PAHO
| ID: pah-7370
Biblioteca responsável:
US1.1
Localização: US1.1, WHO COLL
ABSTRACT
Eight community trials were carried out by the Onchocerciasis Control Programme in West Africa to determine the safety of the new microfilaricide ivermectin during large-scale treatment of onchocersiasis. The trial areas were located in eight different countries and varied greatly in endemicity level; a total of 50,929 persons were treated and monitored for 72 hours. Overall treatment coverage was 60 percent of the census population, the main reasons for non-treatment being the exclusion criteria. Of those treated, 9 percent reported with adverse reactions, 2.4 percent with moderate reactions, and 0.24 percent with severe reactions. Most reactions were reported during the first day of follow-up, the most frequent severe reaction being severe symptomatic postural hypotension (in 49 cases). Three cases of severe dyspnoea were life-threatening but their relationship with ivermectin treatment is uncertain. The incidence of adverse reactions was directly related to skin microfilarial load and was highest in the foci with the highest endemicity levels. Treatment resulted in 98 percent reductions in mean microfilarial loads at all endemicity levels. The benefit of treatment largely compensated for the discomfort due to adverse reactions, which were all transient and managed successfully. Ivermectin thus appears to be ...(AU)
Buscar no Google
Coleções:
Bases de dados de organismos internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Helmintíase
/
Doenças Negligenciadas
/
Oncocercose
/
Zoonoses
Base de dados:
PAHO
Assunto principal:
Oncocercose
/
Ivermectina
/
Microfilárias
País/Região como assunto:
África
Idioma:
Inglês
Revista:
Bulletin of the World Health Organization (WHO)
Ano de publicação:
1989
Tipo de documento:
Artigo