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Remdesivir-Ivermectin combination displays synergistic interaction with improved in vitro antiviral activity against SARS-CoV-2
Laura Jeffreys; Shaun H Pennington; Jack Duggan; Claire H Caygill; Rose C Lopeman; Alastair Breen; Jessica Jinks; Alison Ardrey; Samantha Donnellan; Edward I Patterson; Grant I Hughes; W. David Hong; Ghaith Aljayyoussi; Andrew Owen; Steve A Ward; Giancarlo A Biagini.
Afiliação
  • Laura Jeffreys; Liverpool School of Tropical Medicine
  • Shaun H Pennington; Liverpool School of Tropical Medicine
  • Jack Duggan; Liverpool School of Tropical Medicine
  • Claire H Caygill; Liverpool School of Tropical Medicine
  • Rose C Lopeman; Liverpool School of Tropical Medicine
  • Alastair Breen; Liverpool School of Tropical Medicine
  • Jessica Jinks; Liverpool School of Tropical Medicine
  • Alison Ardrey; Liverpool School of Tropical Medicine
  • Samantha Donnellan; Liverpool School of Tropical Medicine
  • Edward I Patterson; Liverpool School of Tropical Medicine
  • Grant I Hughes; Liverpool School of Tropical Medicine
  • W. David Hong; University of Liverpool
  • Ghaith Aljayyoussi; Liverpool School of tropical Medicine
  • Andrew Owen; University of Liverpool
  • Steve A Ward; Liverpool School of Tropical Medicine
  • Giancarlo A Biagini; Liverpool School of Tropical Medicine
Preprint em En | PREPRINT-BIORXIV | ID: ppbiorxiv-424232
ABSTRACT
A key element for the prevention and management of COVID-19 is the development of effective therapeutics. Drug combination strategies of repurposed drugs offer several advantages over monotherapies, including the potential to achieve greater efficacy, the potential to increase the therapeutic index of drugs and the potential to reduce the emergence of drug resistance. Here, we report on the in vitro synergistic interaction between two FDA approved drugs, remdesivir and ivermectin resulting in enhanced antiviral activity against SARS-CoV-2. These findings warrant further investigations into the clinical potential of this combination, together with studies to define the underlying mechanism.
Licença
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Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-BIORXIV Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-BIORXIV Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint