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Sexually dimorphic placental responses to maternal SARS-CoV-2 infection
Evan A Bordt; Lydia L Shook; Caroline Atyeo; Krista M Pullen; Rose M De Guzman; Marie-Charlotte Meinsohn; Maeva Chauvin; Stephanie Fischinger; Laura J Yockey; Kaitlyn James; Rosiane Lima; Lael M Yonker; Alessio Fasano; Sara Brigida; Lisa M Bebell; Drucilla J Roberts; David Pepin; Jun R Huh; Staci D Bilbo; Jonathan Z Li; Anjali Kaimal; Kathryn J Gray; Douglas Lauffenburger; Galit Alter; Andrea G Edlow.
Afiliação
  • Evan A Bordt; Department of Pediatrics, Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  • Lydia L Shook; Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Vincent Center for Reproductive Biology, Massa
  • Caroline Atyeo; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; PhD Program in Virology, Division of Medical Sciences, Harvard University, Boston, MA, USA
  • Krista M Pullen; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
  • Rose M De Guzman; Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Vincent Center for Reproductive Biology, Massa
  • Marie-Charlotte Meinsohn; Pediatric Surgical Research Laboratories, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
  • Maeva Chauvin; Pediatric Surgical Research Laboratories, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
  • Stephanie Fischinger; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA
  • Laura J Yockey; Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Vincent Center for Reproductive Biology, Massa
  • Kaitlyn James; Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  • Rosiane Lima; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA; Department of Pediatrics, Massachusetts General Hospital, Boston, MA
  • Lael M Yonker; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA; Department of Pediatrics, Massachusetts General Hospital, Boston, MA
  • Alessio Fasano; Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA; Department of Pediatrics, Massachusetts General Hospital, Boston, MA
  • Sara Brigida; Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Vincent Center for Reproductive Biology, Massa
  • Lisa M Bebell; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA
  • Drucilla J Roberts; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  • David Pepin; Pediatric Surgical Research Laboratories, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
  • Jun R Huh; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and B
  • Staci D Bilbo; Department of Pediatrics, Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Duke University, Department of Psyc
  • Jonathan Z Li; Department of Medicine, Brigham and Womens Hospital, Boston, MA, USA
  • Anjali Kaimal; Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  • Kathryn J Gray; Department of Obstetrics and Gynecology, Brigham and Womens Hospital, Harvard Medical School, Boston, MA, USA
  • Douglas Lauffenburger; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
  • Galit Alter; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA
  • Andrea G Edlow; Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Vincent Center for Reproductive Biology, Massa
Preprint em En | PREPRINT-BIORXIV | ID: ppbiorxiv-437516
ABSTRACT
There is a persistent male bias in the prevalence and severity of COVID-19 disease. Underlying mechanisms accounting for this sex difference remain incompletely understood. Interferon responses have been implicated as a modulator of disease in adults, and play a key role in the placental anti-viral response. Moreover, the interferon response has been shown to alter Fc-receptor expression, and therefore may impact placental antibody transfer. Here we examined the intersection of viral-induced placental interferon responses, maternal-fetal antibody transfer, and fetal sex. Placental interferon stimulated genes (ISGs), Fc-receptor expression, and SARS-CoV-2 antibody transfer were interrogated in 68 pregnancies. Sexually dimorphic placental expression of ISGs, interleukin-10, and Fc receptors was observed following maternal SARS-CoV-2 infection, with upregulation in males. Reduced maternal SARS-CoV-2-specific antibody titers and impaired placental antibody transfer were noted in pregnancies with a male fetus. These results demonstrate fetal sex-specific maternal and placental adaptive and innate immune responses to SARS-CoV-2.
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Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-BIORXIV Tipo de estudo: Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-BIORXIV Tipo de estudo: Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint