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Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the UK B.1.1.7 and SA B.1.351 variant
Anne Weiss; Franck Touret; Cecile Baronti; Magali Gilles; Bruno Hoen; Antoine Nougairede; Xavier de Lamballerie; Morten Otto Alexander Sommer.
Afiliação
  • Anne Weiss; UNION therapeutics Research Service, Novo Nordisk Center for Biosustainability, Technical University Denmark
  • Franck Touret; Unite des Virus Emergents, Marseille, France
  • Cecile Baronti; Unite des Virus Emergents, Marseille, France
  • Magali Gilles; Unite des Virus Emergents, Marseille, France
  • Bruno Hoen; Institute Pasteur, France
  • Antoine Nougairede; Unite des Virus Emergents
  • Xavier de Lamballerie; Aix Marseille Univ, IRD French Institute of Research for Development, EHESP French School of Public Health & IHU Mediterranee Infection, APHM Public Hospitals o
  • Morten Otto Alexander Sommer; Technical University of Denmark, UNION therapeutics
Preprint em Inglês | bioRxiv | ID: ppbiorxiv-441457
ABSTRACT
SARS-CoV-2 variants are emerging with potential increased transmissibility highlighting the great unmet medical need for new therapies. Niclosamide is a potent anti-SARS-CoV-2 agent that has advanced in clinical development. We validate the potent antiviral efficacy of niclosamide in a SARS-CoV-2 human airway model. Furthermore, niclosamide is effective against the D614G, B.1.1.7 and B.1.351 variants. Our data further support the potent anti-SARS-CoV-2 properties of niclosamide and highlights its great potential as a therapeutic agent for COVID-19.
Licença
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Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
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