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Breadth of concomitant immune responses underpinning viral clearance and patient recovery in a non-severe case of COVID-19
Irani Thevarajan; Thi HO Nguyen; Marios Koutsakos; Julian Druce; Leon Caly; Carolien E van de Sandt; Xiaoxiao Jia; Suellen Nicholson; Mike Catton; Benjamin Cowie; Steven Tong; Sharon Lewin; Katherine Kedzierska.
Afiliação
  • Irani Thevarajan; VIDS/Doherty Institute
  • Thi HO Nguyen; University of Melbourne/Doherty Institute
  • Marios Koutsakos; University of Melbourne/Doherty Institute
  • Julian Druce; VIDRL/Doherty Institute
  • Leon Caly; VIDRL/Doherty Institute
  • Carolien E van de Sandt; University of Melbourne/Doherty Institute
  • Xiaoxiao Jia; University of Melbourne/Doherty Institute
  • Suellen Nicholson; VIDRL/Doherty Institute
  • Mike Catton; VIDRL/Doherty Institute
  • Benjamin Cowie; VIDS/Doherty Institute
  • Steven Tong; VIDS/Doherty Institute
  • Sharon Lewin; Doherty Institute
  • Katherine Kedzierska; University of Melbourne/Doherty Institute
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20025841
ABSTRACT
We report the kinetics of the immune response in relation to clinical and virological features of a patient with mild-to-moderate coronavirus disease-19 (COVID-19) requiring hospitalisation. Increased antibody-secreting cells, follicular T-helper cells, activated CD4+ and CD8+ T-cells and IgM/IgG SARS-CoV-2-binding antibodies were detected in blood, prior to symptomatic recovery. These immunological changes persisted for at least 7 days following full resolution of symptoms, indicating substantial anti-viral immunity in this non-severe COVID-19.
Licença
cc_by_nc_nd
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint