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Steroid-responsive severe encephalopathy in SARS-CoV-2 infection
Andrea Pilotto; SIlvia Odolini; Stefano Masciocchi; Agnese Comelli; Irene Volonghi; Stefano Gazzina; Sara Nocivelli; Alessandro Pezzini; Emanuele Focà; Arnaldo Caruso; Matilde Leonardi; Maria Pia Pasolini; Roberto Gasparotti; Francesco Castelli; Nicholas J Ashton; Kaj Blennow; Henrik Zetterberg; Alessandro Padovani.
Afiliação
  • Andrea Pilotto; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy
  • SIlvia Odolini; University Division of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy
  • Stefano Masciocchi; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy
  • Agnese Comelli; University Division of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy
  • Irene Volonghi; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy
  • Stefano Gazzina; Neurophysiology Unit, ASST Spedali Civili of Brescia, Italy
  • Sara Nocivelli; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy
  • Alessandro Pezzini; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy
  • Emanuele Focà; University Division of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy
  • Arnaldo Caruso; Microbiology Unit, Department of Molecular and Translational Medicine, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy
  • Matilde Leonardi; Neurology, Public Health, Disability Unit - IRCCS Neurology Institute Besta, Milan, Italy
  • Maria Pia Pasolini; Neurophysiology Unit, ASST Spedali Civili of Brescia, Italy
  • Roberto Gasparotti; Euroradiology Unit, Department of Molecular and Translational Medicine, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy
  • Francesco Castelli; University Division of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy
  • Nicholas J Ashton; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
  • Kaj Blennow; Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
  • Henrik Zetterberg; University of Gothenburg
  • Alessandro Padovani; Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy
Preprint em Inglês | medRxiv | ID: ppmedrxiv-20062646
ABSTRACT
Covid-19 infection has the potential for targeting the central nervous system and several neurological symptoms have been described in patients with severe respiratory distress. Here we described the case of a 60-year old subject with SARS-CoV-2 infection but only mild respiratory abnormalities who developed an akinetic mutism due to encephalitis. MRI was negative whereas EEG showed generalized theta slowing. CSF analyses during the acute stage were negative for SARS-CoV-2, positive for pleocytosis and hyperproteinorrachia, and showed increased IL-8 and TNF- concentrations while other infectious or autoimmune disorders were excluded. A progressive clinical improvement along with a reduction of CSF parameters was observed after high-dose steroid treatment, thus arguing for an inflammatory-mediated brain involvement related to Covid-19.
Licença
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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
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