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The landscape of host genetic factors involved in infection to common viruses and SARS-CoV-2
Linda Kachuri; Stephen S Francis; Maike Morrison; George Wendt; Yohan Bossé; Taylor B Cavazos; Sara R Rashkin; Elad Ziv; John S Witte.
Afiliação
  • Linda Kachuri; University of California, San Francisco
  • Stephen S Francis; University of California, San Francisco
  • Maike Morrison; The University of Texas at Austin
  • George Wendt; University of California San Francisco
  • Yohan Bossé; Laval University
  • Taylor B Cavazos; University of California, San Francisco
  • Sara R Rashkin; University of California, San Francisco
  • Elad Ziv; University of California, San Francisco
  • John S Witte; University of California, San Francisco
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20088054
ABSTRACT
IntroductionHumans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the genetic mechanisms of immune response to viral infection provides insight into disease etiology and therapeutic opportunities. MethodsWe conducted a comprehensive study including genome-wide and transcriptome-wide association analyses to identify genetic loci associated with immunoglobulin G antibody response to 28 antigens for 16 viruses using serological data from 7924 European ancestry participants in the UK Biobank cohort. ResultsSignals in human leukocyte antigen (HLA) class II region dominated the landscape of viral antibody response, with 40 independent loci and 14 independent classical alleles, 7 of which exhibited pleiotropic effects across viral families. We identified specific amino acid (AA) residues that are associated with seroreactivity, the strongest associations presented in a range of AA positions within DR{beta}i at positions 11, 13, 71, and 74 for Epstein-Barr Virus (EBV), Varicella Zoster Virus (VZV), Human Herpes virus 7, (HHV7) and Merkel cell polyomavirus (MCV). Genome-wide association analyses discovered 7 novel genetic loci outside the HLA associated with viral antibody response (P<5.0x10-8), including FUT2 (19q13.33) for human polyomavirus BK (BKV), STING1 (5q31.2) for MCV, as well as CXCR5 (11q23.3) and TBKBP1 (17q21.32) for HHV7. Transcriptome-wide association analyses identified 114 genes associated with response to viral infection, 12 outside of the HLA region, including ECSCR P=5.0*10-15 (MCV), NTN5 P=1.1x10-9 (BKV), and P2RY13 P=1.1x10-8 EBV nuclear antigen. We also demonstrated pleiotropy between viral response genes and complex diseases; from autoimmune disorders to cancer to neurodegenerative and psychiatric conditions. ConclusionsOur study confirms the importance of the HLA region in host response to viral infection and elucidates novel genetic determinants beyond the HLA that contribute to host-virus interaction.
Licença
cc_by_nc
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Cohort_studies / Etiology_studies / Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Cohort_studies / Etiology_studies / Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint