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Genomic epidemiology of SARS-CoV-2 in Colombia
Katherine Laiton-Donato; Christian Julian Villabona Arenas; Jose A Usme Ciro; Carlos Franco Munoz; Diego Alejandro Alvarez-Diaz; Liz S Villabona-Arenas; Susy Echeverria-Londono; Nicolas D Franco-Sierra; Zulma M Cucunuba; Astrid Carolina Florez-Sanchez; Carolina Ferro; Nadim J Ajami; Diana M Walteros; Franklin E Prieto-Alvarado; Carlos A Duran-Camacho; Martha L Ospina-Martinez; Marcela M Mercado-Reyes.
Afiliação
  • Katherine Laiton-Donato; Instituto Nacional de Salud
  • Christian Julian Villabona Arenas; London School of Hygiene & Tropical Medicine
  • Jose A Usme Ciro; Universidad Cooperativa de Colombia
  • Carlos Franco Munoz; Instituto Nacional de Salud
  • Diego Alejandro Alvarez-Diaz; Instituto Nacional de Salud
  • Liz S Villabona-Arenas; Universidad Industrial de Santander
  • Susy Echeverria-Londono; Imperial College-London
  • Nicolas D Franco-Sierra; Instituto de Investigacion de Recursos Biologicos Alexander von Humboldt
  • Zulma M Cucunuba; Imperial College London
  • Astrid Carolina Florez-Sanchez; Instituto Nacional de Salud
  • Carolina Ferro; Instituto Nacional de Salud
  • Nadim J Ajami; Baylor College of Medicine
  • Diana M Walteros; Instituto Nacional de Salud
  • Franklin E Prieto-Alvarado; Instituto Nacional de Salud
  • Carlos A Duran-Camacho; Instituto Nacional de Salud
  • Martha L Ospina-Martinez; Instituto Nacional de Salud
  • Marcela M Mercado-Reyes; Instiuto Nacional de Salud
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20135715
ABSTRACT
Coronavirus disease 2019 (COVID-19) was first diagnosed in Colombia from a traveler arriving from Italy on February 26, 2020. To date, available data on the origins and number or introductions of SARS-CoV-2 into the country are limited. Here, we sequenced SARS-CoV-2 from 43 clinical samples and--together with other 73 genomes sequences available from the country--we investigated the emergence and the routes of importation of COVID-19 into Colombia using epidemiological, historical air travel and phylogenetic observations. Our study provided evidence of multiple introductions, mostly from Europe, with at least 12 lineages being documented. Phylogenetic findings validated the lineage diversity, supported multiple importation events and the evolutionary relationship of epidemiologically-linked transmission chains. Our results reconstruct the early evolutionary history of SARS-CoV-2 in Colombia and highlight the advantages of genome sequencing to complement COVID-19 outbreak investigation.
Licença
cc_by_nc_nd
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint