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The Trans-omics Landscape of COVID-19
Peng Wu; Dongsheng Chen; Wencheng Ding; Ping Wu; Hongyan Hou; Yong Bai; Yuwen Zhou; Kezhen Li; Shunian Xiang; Panhong Liu; Jia Ju; Ensong Guo; Jia Liu; Bin Yang; Junpeng Fan; Liang He; Ziyong Sun; Ling Feng; Jian Wang; Tangchun Wu; Hao Wang; Jin Cheng; Hui Xing; Yifan Meng; Yongsheng Li; Yuanliang Zhang; Hongbo Luo; Gang Xie; Xianmei Lan; Ye Tao; Hao Yuan; Kang Huang; Wan Sun; Xiaobo Qian; Zhichao Li; Mingxi Huang; Peiwen Ding; Haoyu Wang; Jiaying Qiu; Feiyue Wang; Shiyou Wang; Jiacheng Zhu; Xiangning Ding; Chaochao Chai; Langchao Liang; Xiaoling Wang; Lihua Luo; Yuzhe Sun; Ying Yang; Zhenkun Zhuang; Tao Li; Lei Tian; Shaoqiao Zhang; Linnan Zhu; Lei Chen; Yiquan Wu; Xiaoyan Ma; Fang Chen; Yan Ren; Xun Xu; Siqi Liu; Jian Wang; Huanming Yang; Lin Wang; Chaoyang Sun; Ding Ma; Xin Jin; Gang Chen.
Afiliação
  • Peng Wu; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Techno
  • Dongsheng Chen; BGI-Shenzhen, Shenzhen 518083, China
  • Wencheng Ding; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Techno
  • Ping Wu; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Techno
  • Hongyan Hou; Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • Yong Bai; BGI-Shenzhen, Shenzhen 518083, China
  • Yuwen Zhou; 1.BGI-Shenzhen, Shenzhen 518083, China; 2.BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Kezhen Li; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Techno
  • Shunian Xiang; BGI-Shenzhen, Shenzhen 518083, China
  • Panhong Liu; 1.BGI-Shenzhen, Shenzhen 518083, China; 2.BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Jia Ju; 1.BGI-Shenzhen, Shenzhen 518083, China; 2.BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Ensong Guo; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Techno
  • Jia Liu; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Techno
  • Bin Yang; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Techno
  • Junpeng Fan; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Techno
  • Liang He; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Techno
  • Ziyong Sun; Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • Ling Feng; Department of Gynecology and obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • Jian Wang; Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
  • Tangchun Wu; Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong Univers
  • Hao Wang; Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong Univers
  • Jin Cheng; Department of Research, Xiangyang Central Hospital, Hubei University of Arts and Science, Xiangyang, Hubei, China
  • Hui Xing; Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Hubei University of Arts and Science, Xiangyang, Hubei, China
  • Yifan Meng; Department of Gynecologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University
  • Yongsheng Li; Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China
  • Yuanliang Zhang; BGI-Shenzhen, Shenzhen 518083, China
  • Hongbo Luo; BGI-Shenzhen, Shenzhen 518083, China
  • Gang Xie; 1.BGI-Shenzhen, Shenzhen 518083, China; 2.BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Xianmei Lan; BGI-Shenzhen, Shenzhen 518083, China
  • Ye Tao; BGI-Shenzhen, Shenzhen 518083, China
  • Hao Yuan; 1.BGI-Shenzhen, Shenzhen 518083, China; 2.BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Kang Huang; BGI-Shenzhen, Shenzhen 518083, China
  • Wan Sun; BGI-Shenzhen, Shenzhen 518083, China
  • Xiaobo Qian; 1.BGI-Shenzhen, Shenzhen 518083, China; 2.BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Zhichao Li; 1.BGI-Shenzhen, Shenzhen 518083, China; 2.BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Mingxi Huang; 1.BGI-Shenzhen, Shenzhen 518083, China; 2.BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Peiwen Ding; 1. BGI-Shenzhen, Shenzhen 518083, China; 2. BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Haoyu Wang; 1. BGI-Shenzhen, Shenzhen 518083, China; 2. BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Jiaying Qiu; 1. BGI-Shenzhen, Shenzhen 518083, China; 2. BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Feiyue Wang; 1. BGI-Shenzhen, Shenzhen 518083, China; 2. BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Shiyou Wang; 1. BGI-Shenzhen, Shenzhen 518083, China; 2. BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Jiacheng Zhu; 1. BGI-Shenzhen, Shenzhen 518083, China; 2. BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Xiangning Ding; 1. BGI-Shenzhen, Shenzhen 518083, China; 2. BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Chaochao Chai; 1. BGI-Shenzhen, Shenzhen 518083, China; 2. BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Langchao Liang; 1. BGI-Shenzhen, Shenzhen 518083, China; 2. BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Xiaoling Wang; 1. BGI-Shenzhen, Shenzhen 518083, China; 2. BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Lihua Luo; 1. BGI-Shenzhen, Shenzhen 518083, China; 2. BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China
  • Yuzhe Sun; BGI-Shenzhen, Shenzhen 518083, China
  • Ying Yang; BGI-Shenzhen, Shenzhen 518083, China
  • Zhenkun Zhuang; 1.BGI-Shenzhen, Shenzhen 518083, China; 2.School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China
  • Tao Li; BGI-Shenzhen, Shenzhen 518083, China
  • Lei Tian; BGI-Shenzhen, Shenzhen 518083, China
  • Shaoqiao Zhang; BGI-Hubei, BGI-Shenzhen, Wuhan,430074 , China
  • Linnan Zhu; BGI-Shenzhen, Shenzhen 518083, China
  • Lei Chen; College of Veterinary Medicine, Yangzhou University, Yangzhou, China
  • Yiquan Wu; HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
  • Xiaoyan Ma; Department of Biochemistry, University of Cambridge, UK
  • Fang Chen; BGI-Shenzhen, Shenzhen 518083, China
  • Yan Ren; BGI-Shenzhen, Shenzhen 518083, China
  • Xun Xu; 1.BGI-Shenzhen, Shenzhen 518083, China; 2.Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen, 518120, China
  • Siqi Liu; BGI-Shenzhen, Shenzhen 518083, China
  • Jian Wang; 1.BGI-Shenzhen, Shenzhen 518083, China; 2.James D. Watson Institute of Genome Science, 310008 Hangzhou, China
  • Huanming Yang; 1.BGI-Shenzhen, Shenzhen 518083, China; 2.James D. Watson Institute of Genome Science, 310008 Hangzhou, China
  • Lin Wang; Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
  • Chaoyang Sun; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Techno
  • Ding Ma; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Techno
  • Xin Jin; 1.BGI-Shenzhen, Shenzhen 518083, China; 2.School of Medicine, South China University of Technology, Guangzhou 510006, Guangdong, China
  • Gang Chen; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Techno
Preprint em Inglês | medRxiv | ID: ppmedrxiv-20155150
ABSTRACT
System-wide molecular characteristics of COVID-19, especially in those patients without comorbidities, have not been fully investigated. We compared extensive molecular profiles of blood samples from 231 COVID-19 patients, ranging from asymptomatic to critically ill, importantly excluding those with any comorbidities. Amongst the major findings, asymptomatic patients were characterized by highly activated anti-virus interferon, T/natural killer (NK) cell activation, and transcriptional upregulation of inflammatory cytokine mRNAs. However, given very abundant RNA binding proteins (RBPs), these cytokine mRNAs could be effectively destabilized hence preserving normal cytokine levels. In contrast, in critically ill patients, cytokine storm due to RBPs inhibition and tryptophan metabolites accumulation contributed to T/NK cell dysfunction. A machine-learning model was constructed which accurately stratified the COVID-19 severities based on their multi-omics features. Overall, our analysis provides insights into COVID-19 pathogenesis and identifies targets for intervening in treatment.
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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint