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Reinfection with SARS-CoV-2 and Failure of Humoral Immunity: a case report.
Jason D. Goldman; Kai Wang; Katharina Roltgen; Sandra C. A. Nielsen; Jared C. Roach; Samia N. Naccache; Fan Yang; Oliver F. Wirz; Kathryn E. Yost; Ji-Yeun Lee; Kelly Chun; Terri Wrin; Christos J. Petropoulos; Inyou Lee; Shannon Fallen; Paula M. Manner; Julie A. Wallick; Heather A. Algren; Kim M. Murray; Yapeng Su; Jennifer Hadlock; Joshua Jeharajah; William R. Berrington; George P. Pappas; Sonam T. Nyatsatsang; Alexander L. Greninger; Ansuman T. Satpathy; John S Pauk; Scott D. Boyd; James R. Heath.
Afiliação
  • Jason D. Goldman; Division of Infectious Diseases, Swedish Medical Center, Providence St. Joseph Health, and Division of Allergy and Infectious Diseases, University of Washington
  • Kai Wang; Institute for Systems Biology, Seattle, WA, USA
  • Katharina Roltgen; Department of Pathology, Stanford University, Stanford, CA, USA
  • Sandra C. A. Nielsen; Department of Pathology, Stanford University, Stanford, CA, USA
  • Jared C. Roach; Institute for Systems Biology, Seattle, WA USA
  • Samia N. Naccache; Department of Microbiology, LabCorp, Seattle, WA, USA
  • Fan Yang; Department of Pathology, Stanford University, Stanford, CA, USA
  • Oliver F. Wirz; Department of Pathology, Stanford University, Stanford, CA, USA
  • Kathryn E. Yost; Department of Pathology, Stanford University, Stanford, CA, USA
  • Ji-Yeun Lee; Department of Pathology, Stanford University, Stanford, CA, USA
  • Kelly Chun; LabCorp Esoterix, Calabasas, CA, USA
  • Terri Wrin; Monogram Biosciences, South San Francisco, CA, USA
  • Christos J. Petropoulos; Monogram Biosciences, South San Francisco, CA, USA
  • Inyou Lee; Institute for Systems Biology, Seattle, WA USA
  • Shannon Fallen; Institute for Systems Biology, Seattle, WA, USA
  • Paula M. Manner; Swedish Center for Research and Innovation, Swedish Medical Center, Providence St. Joseph Health, Seattle, WA, USA
  • Julie A. Wallick; Swedish Center for Research and Innovation, Swedish Medical Center, Providence St. Joseph Health, Seattle, WA, USA
  • Heather A. Algren; Swedish Center for Research and Innovation, Swedish Medical Center, Providence St. Joseph Health, Seattle, WA, USA
  • Kim M. Murray; Institute for Systems Biology, Seattle, WA USA
  • Yapeng Su; Institute for Systems Biology, Seattle, WA, USA
  • Jennifer Hadlock; Institute for Systems Biology, Seattle, WA, USA; and Providence St. Joseph Health, Renton, WA, USA
  • Joshua Jeharajah; Division of Infectious Diseases, Polyclinic, Seattle, WA, USA
  • William R. Berrington; Division of Infectious Diseases, Swedish Medical Center, Providence St. Joseph Health, Seattle, WA, USA
  • George P. Pappas; Division of Pulmonology and Critical Care Medicine, Swedish Medical Center, Providence St. Joseph Health, Seattle, WA, USA
  • Sonam T. Nyatsatsang; Division of Infectious Diseases, Swedish Medical Center, Providence St. Joseph Health, Seattle, WA, USA
  • Alexander L. Greninger; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine; Vaccine and Infectious Disease Division, Fred Hutch, Seattle, WA,
  • Ansuman T. Satpathy; Department of Pathology, Stanford University, Stanford, CA, USA
  • John S Pauk; Division of Infectious Diseases, Swedish Medical Center, Providence St. Joseph Health, Seattle, WA, USA
  • Scott D. Boyd; Department of Pathology, Stanford University, and Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA
  • James R. Heath; Institute for Systems Biology, Seattle, WA, USA
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20192443
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ABSTRACT
Recovery from COVID-19 is associated with production of anti-SARS-CoV-2 antibodies, but it is uncertain whether these confer immunity. We describe viral RNA shedding duration in hospitalized patients and identify patients with recurrent shedding. We sequenced viruses from two distinct episodes of symptomatic COVID-19 separated by 144 days in a single patient, to conclusively describe reinfection with a new strain harboring the spike variant D614G. With antibody and B cell analytics, we show correlates of adaptive immunity, including a differential response to D614G. Finally, we discuss implications for vaccine programs and begin to define benchmarks for protection against reinfection from SARS-CoV-2.
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Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Case_reports Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Case_reports Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint