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Variability of Salivary and Nasal Specimens for SARS-CoV-2 Detection
Yukari C Manabe; Carolyn Reuland; Tong Yu; Razvan Azamfirei; Taylor Church; Diane M Brown; Thelio T Sewell; Justin P Hardick; Paul W Blair; Christopher D Heaney; Andrew Pekosz; David L Thomas.
Afiliação
  • Yukari C Manabe; Johns Hopkins University School of Medicine
  • Carolyn Reuland; Johns Hopkins University School of Medicine
  • Tong Yu; Johns Hopkins University School of Medicine
  • Razvan Azamfirei; Johns Hopkins University School of Medicine
  • Taylor Church; Johns Hopkins University School of Medicine
  • Diane M Brown; Johns Hopkins University School of Medicine
  • Thelio T Sewell; Johns Hopkins University School of Medicine
  • Justin P Hardick; Johns Hopkins University School of Medicine
  • Paul W Blair; Johns Hopkins University School of Medicine
  • Christopher D Heaney; Johns Hopkins Bloomberg School of Public Health
  • Andrew Pekosz; Johns Hopkins Bloomberg School of Public Health
  • David L Thomas; Johns Hopkins University School of Medicine
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20208520
ABSTRACT
In a large cohort of ambulatory confirmed COVID-19 patients with multiple self-collected sample time points, we compared 202 matched nasal-oropharyngeal swabs and oral salivary fluid sample pairs by RT-PCR. Nasal-oropharyngeal swabs were more sensitive than this salivary sample type (oral crevicular fluid) suggesting that not all saliva sample types have equivalent sensitivity. However, all samples that were Vero E6-TMPRSS2 cell culture positive (e.g., infectious virus) were also oral fluid RT-PCR positive suggesting that oral fluid may find the patients most likely to transmit disease to others.
Licença
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Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Cohort_studies / Diagnostic_studies / Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Cohort_studies / Diagnostic_studies / Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint
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