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Epidemiological and immunological features of obesity and SARS-CoV-2
Eric James Nilles; Sameed Siddiqui; Stephanie Fischinger; Yannic C Bartsch; Michael De St Aubin; Guohai Zhou; Matthew J Gluck; Samuel Berger; Justin Rhee; Eric Petersen; Benjamin Mormann; MIchael A Loesche; Zhilin Chen; Jingyou Yu; Makda Gebre; Caroline Ayteo; Alex Lee Zhu; Matthew J Gorman; John Burke; Matthew Slein; Mohammad A Hasdianda; Guruprasad Jambaulikar; Edward Boyer; Pardis Sabeti; Dan H Barouch; Boris D Julg; Adam J Kucharski; Elon R Musk; Douglas A Lauffenburger; Galit Alter; Anil S Menon.
Afiliação
  • Eric James Nilles; Brigham and Women's Hospital; Harvard Medical School; Harvard Humanitarian Initiative; Massachusetts Consortium on Pathogen Readiness,
  • Sameed Siddiqui; Massachusetts Institute of Technology; Broad Institute of MIT and Harvard
  • Stephanie Fischinger; Ragon Institute of MGH, MIT and Harvard
  • Yannic C Bartsch; Ragon Institute of MGH, MIT and Harvard
  • Michael De St Aubin; Harvard Humanitarian Initiative
  • Guohai Zhou; Brigham and Women's Hospital
  • Matthew J Gluck; Space Exploration Technologies Corp.
  • Samuel Berger; Space Exploration Technologies Corp
  • Justin Rhee; Space Exploration Technologies Corp
  • Eric Petersen; Space Exploration Technologies Corp
  • Benjamin Mormann; Space Exploration Technologies Corp
  • MIchael A Loesche; Space Exploration Technologies Corp; Brigham and Women's Hospital
  • Zhilin Chen; Ragon Institute of MGH, MIT and Harvard,
  • Jingyou Yu; Ragon Institute of MGH, MIT and Harvard; Harvard T.H. Chan School of Public Health
  • Makda Gebre; Ragon Institute of MGH, MIT and Harvard
  • Caroline Ayteo; Ragon Institute of MGH, MIT and Harvard
  • Alex Lee Zhu; Ragon Institute of MGH, MIT and Harvard
  • Matthew J Gorman; Ragon Institute of MGH, MIT and Harvard
  • John Burke; Ragon Institute of MGH, MIT and Harvard
  • Matthew Slein; Ragon Institute of MGH, MIT and Harvard
  • Mohammad A Hasdianda; Brigham and Women's Hospital; Harvard Medical School
  • Guruprasad Jambaulikar; Brigham and Women's Hospital; Harvard Medical School
  • Edward Boyer; Brigham and Women's Hospital; Harvard Medical School
  • Pardis Sabeti; Harvard University; The Broad Institute of MIT and Harvard; Howard Hughes Medical Institute; Massachusetts Consortium on Pathogen Readiness
  • Dan H Barouch; Broad Institute of MIT and Harvard, Cambridg; Beth Israel Deaconess Medical Center; Harvard Medical School
  • Boris D Julg; Broad Institute of MIT and Harvard
  • Adam J Kucharski; London School of Hygiene & Tropical Medicine
  • Elon R Musk; Space Exploration Technologies Corp
  • Douglas A Lauffenburger; Massachusetts Institute of Technology
  • Galit Alter; Ragon Institute of MGH, MIT, and Harvard; Massachusetts Consortium on Pathogen Readiness
  • Anil S Menon; Space Exploration Technologies Corp
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20229724
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ABSTRACT
Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response are poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and, remarkably homogenous immune activity across BMI categories suggests natural- and vaccine-induced protection may be similar across these groups.
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Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Cohort_studies / Experimental_studies / Observational_studies / Prognostic_studies / Rct Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Cohort_studies / Experimental_studies / Observational_studies / Prognostic_studies / Rct Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint