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Adaptive immunity to SARS-CoV-2 in cancer patients: The CAPTURE study
Annika Fendler; Lewis Au; Laura Amanda Boos; Fiona Byrne; Scott Thomas Colville Shepherd; Ben Shum; Camille L Gerard; Barry Ward; Wenyi Xie; Maddalena Cerrone; Georgina H Cornish; Martin Pule; Leila Mekkaoui; Kevin Ng; Richard Stone; Camilla Gomes; Helen R Flynn; Ana Agua-Doce; Phillip Hobson; Simon Caidan; Mike Howell; Robert Goldstone; Mike Gavrielides; Emma Nye; Bram Snijders; James Macrae; Jerome Nicod; Adrian Hayday; Firza Gronthoud; Christina Messiou; David Cunningham; Ian Chau; Naureen Starling; Nicholas Turner; Jennifer Rusby; Liam Welsh; Nicholas van As; Robin Jones; Joanne Droney; Susana Banerjee; Kate Tatham; Shaman Jhanji; Olivia Curtis; Kevin Harrington; Shreerang Bhide; Tim Slattery; Yasir Khan; Zayd Tippu; Isla Leslie; Spyridon Gennatas; Alicia Okines; Alison Reid; Kate Young; Andrew Furness; Lisa Pickering; Sonia Ghandi; Steve Gamblin; Charles Swanton; Emma Nicholson; Sacheen Kumar; Nadia Yousaf; Katalin Andrea Wilkinson; Anthony Swerdlow; Ruth Harvey; George Kassiotis; Robert Wilkinson; James Larkin; Samra Turajlic.
Afiliação
  • Annika Fendler; The Francis Crick Institute
  • Lewis Au; The Francis Crick Institute
  • Laura Amanda Boos; The Royal Marsden NHS Foundation Trust
  • Fiona Byrne; The Francis Crick Institute
  • Scott Thomas Colville Shepherd; The Francis Crick Institute
  • Ben Shum; The Francis Crick Institute
  • Camille L Gerard; The Francis Crick Institute
  • Barry Ward; The Francis Crick Institute
  • Wenyi Xie; The Francis Crick Institute
  • Maddalena Cerrone; The Francis Crick Institute
  • Georgina H Cornish; The Francis Crick Institute
  • Martin Pule; Autolus Limited, The MediaWorks
  • Leila Mekkaoui; Autolus Limited, The MediaWorks
  • Kevin Ng; The Francis Crick Institute
  • Richard Stone; The Francis Crick Institute
  • Camilla Gomes; The Francis Crick Institute
  • Helen R Flynn; The Francis Crick Institute
  • Ana Agua-Doce; The Francis Crick Institute
  • Phillip Hobson; The Francis Crick Institute
  • Simon Caidan; The Francis Crick Institute
  • Mike Howell; The Francis Crick Institute
  • Robert Goldstone; The Francis Crick Institute
  • Mike Gavrielides; The Francis Crick Institute
  • Emma Nye; The Francis Crick Institute
  • Bram Snijders; The Francis Crick Institute
  • James Macrae; The Francis Crick Institute
  • Jerome Nicod; The Francis Crick Institute
  • Adrian Hayday; The Francis Crick Institute
  • Firza Gronthoud; The Royal Marsden NHS Foundation Trust
  • Christina Messiou; The Royal Marsden NHS Foundation Trust
  • David Cunningham; The Royal Marsden NHS Foundation Trust
  • Ian Chau; The Royal Marsden NHS Foundation Trust
  • Naureen Starling; The Royal Marsden NHS Foundation Trust
  • Nicholas Turner; The Royal Marsden NHS Foundation Trust
  • Jennifer Rusby; The Royal Marsden NHS Foundation Trust
  • Liam Welsh; The Royal Marsden NHS Foundation Trust
  • Nicholas van As; The Royal Marsden NHS Foundation Trust
  • Robin Jones; The Royal Marsden NHS Foundation Trust
  • Joanne Droney; The Royal Marsden NHS Foundation Trust
  • Susana Banerjee; The Royal Marsden NHS Foundation Trust
  • Kate Tatham; The Royal Marsden NHS Foundation Trust
  • Shaman Jhanji; The Royal Marsden NHS Foundation Trust
  • Olivia Curtis; The Royal Marsden NHS Foundation Trust
  • Kevin Harrington; The Royal Marsden NHS Foundation Trust
  • Shreerang Bhide; The Royal Marsden NHS Foundation Trust
  • Tim Slattery; The Royal Marsden NHS Foundation Trust
  • Yasir Khan; The Royal Marsden NHS Foundation Trust
  • Zayd Tippu; The Royal Marsden NHS Foundation Trust
  • Isla Leslie; The Royal Marsden NHS Foundation Trust
  • Spyridon Gennatas; The Royal Marsden NHS Foundation Trust
  • Alicia Okines; The Royal Marsden NHS Foundation Trust
  • Alison Reid; The Royal Marsden NHS Foundation Trust
  • Kate Young; The Royal Marsden NHS Foundation Trust
  • Andrew Furness; The Royal Marsden NHS Foundation Trust
  • Lisa Pickering; The Royal Marsden NHS Foundation Trust
  • Sonia Ghandi; The Francis Crick Institute
  • Steve Gamblin; The Francis Crick Institute
  • Charles Swanton; The Francis Crick Institute
  • Emma Nicholson; The Royal Marsden NHS Foundation Trust
  • Sacheen Kumar; The Royal Marsden NHS Foundation Trust
  • Nadia Yousaf; The Royal Marsden NHS Foundation Trust
  • Katalin Andrea Wilkinson; The Francis Crick Institute
  • Anthony Swerdlow; The Institute of Cancer Research
  • Ruth Harvey; The Francis Crick Institute
  • George Kassiotis; The Francis Crick Institute
  • Robert Wilkinson; The Francis Crick Institute
  • James Larkin; The Royal Marsden NHS Foundation Trust
  • Samra Turajlic; The Francis Crick Institute
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20248608
ABSTRACT
There is a pressing need to characterise the nature, extent and duration of immune response to SARS-CoV-2 in cancer patients and inform risk-reduction strategies and preserve cancer outcomes. CAPTURE is a prospective, longitudinal cohort study of cancer patients and healthcare workers (HCWs) integrating longitudinal immune profiling and clinical annotation. We evaluated 529 blood samples and 1051 oronasopharyngeal swabs from 144 cancer patients and 73 HCWs and correlated with >200 clinical variables. In patients with solid cancers and HCWs, S1-reactive and neutralising antibodies to SARS-CoV-2 were detectable five months post-infection. SARS-CoV-2-specific T-cell responses were detected, and CD4+ T-cell responses correlated with S1 antibody levels. Patients with haematological malignancies had impaired but partially compensated immune responses. Overall, cancer stage, disease status, and therapies did not correlate with immune responses. These findings have implications for understanding individual risks and potential effectiveness of SARS-CoV-2 vaccination in the cancer population.
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Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Cohort_studies / Experimental_studies / Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Cohort_studies / Experimental_studies / Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint