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Evaluation of Urine SARS-COV-2 RT-PCR as a predictor of Acute Kidney Injury and disease severity in critical COVID-19 patients
Sergio Pinto de Souza; Marcelo Augusto Duarte Silveira; Bruno Solano de Freitas Souza; Carolina Kymie Vasques Nonaka; Erica de Melo; Julia Barros Cabral; Fernanda Coelho; Rogerio da Hora Passos.
Afiliação
  • Sergio Pinto de Souza; Hospital Sao Rafael
  • Marcelo Augusto Duarte Silveira; Hospital Sao Rafael
  • Bruno Solano de Freitas Souza; Hospital Sao Rafael
  • Carolina Kymie Vasques Nonaka; Hospital Sao Rafael
  • Erica de Melo; Hospital Sao Rafael
  • Julia Barros Cabral; Hospital Sao Rafael
  • Fernanda Coelho; Hospital Sao Rafael
  • Rogerio da Hora Passos; Hospital Sao Rafael
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21249576
ABSTRACT
The novel coronavirus disease (COVID-19) is an emerging infectious disease caused by SARS-CoV-2, which began as an outbreak in Wuhan, China and spread rapidly throughout the globe. Although the majority of infections are mild, severe and critical COVID-19 patients face deterioration of respiratory function, and may also present extrapulmonary manifestations, mostly affecting the kidney, digestive tract, heart and nervous system. Here, we prospectively evaluated the presence of SARS-CoV-2 genetic material by RT-PCR in urine samples obtained from critical care COVID-19 patients. In 51 patients included, we found higher serum creatinine levels, a longer hospital stay and a more frequent dialysis need in urine-positive patients. These findings could suggest that, in predisposed patients, a direct viral cytopathic effect may contribute to a more severe disease phenotype.
Licença
cc_by_nc_nd
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Experimental_studies / Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Experimental_studies / Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint