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Vascular Inflammation in Lungs of Patients with Fatal Coronavirus Disease 2019 (COVID-19) Infection: Possible role for the NLRP3 inflammasome
Oindrila Paul; Jian Qin Tao; Leslie Litzky; Michael Feldman; Kathleen Montone; Chamith Rajapakse; Christian Bermudez; Shampa Chatterjee.
Afiliação
  • Oindrila Paul; Institute for Environmental Medicine and Department of Physiology, University of Pennsylvania
  • Jian Qin Tao; Institute for Environmental Medicine and Department of Physiology, University of Pennsylvania
  • Leslie Litzky; Department of Pathology, University of Pennsylvania
  • Michael Feldman; Department of Pathology, University of Pennsylvania
  • Kathleen Montone; Department of Pathology, University of Pennsylvania
  • Chamith Rajapakse; Department of Radiology, University of Pennsylvania
  • Christian Bermudez; Department of Surgery, University of Pennsylvania
  • Shampa Chatterjee; Institute for Environmental Medicine and Department of Physiology, University of Pennsylvania
Preprint em Inglês | medRxiv | ID: ppmedrxiv-21253815
ABSTRACT
Hyperinflammation is a key event that occurs with SARS-CoV-2 infection. In the lung, hyperinflammation leads to structural damage to tissue. To date, numerous lung histological studies have shown extensive alveolar damage, but there is scarce documentation of vascular inflammation in postmortem lung tissue. Here we document histopathological features and monitor the NLRP3 inflammasome in fatal cases of disease caused by SARS Cov2 (COVID-19). We posit that inflammasome formation along the vessel wall is a characteristic of lung inflammation that accompanies COVID-19 and that it is a probable candidate that drives amplification of inflammation post infection.
Licença
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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
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