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Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein
Sarah Lapidus; Feimei Liu; Arnau Casanovas-Massana; Yile Dai; John D. Huck; Carolina Lucas; Jon Klein; Renata B. Filler; Madison S. Strine; Mouhamad Sy; Awa B. Deme; Aida S. Badiane; Baba Dieye; Ibrahima Mbaye Ndiaye; Younous Diedhiou; Amadou Moctar Mbaye; Cheikh Tidiane Diagne; Inés Vigan-Womas; Alassane Mbengue; Bacary D. Sadio; Moussa M. Diagne; Adam J. Moore; Khadidiatou Mangou; Fatoumata Diallo; Seynabou D. Sene; Mariama N. Pouye; Rokhaya Faye; Babacar Diouf; Nivison Nery Jr; Federico Costa; Mitermayer Reis; M. Catherine Muenker; Daniel Z. Hodson; Yannick Mbarga; Ben Z. Katz; Jason R. Andrews; Melissa Campbell; Ariktha Srivathsan; Kathy Kamath; Elisabeth Baum-Jones; Ousmane Faye; Amadou Alpha Sall; Juan Carlos Quintero Vélez; Michael Cappello; Michael Wilson; Choukri Ben-Mamoun; Fabrice A. Somé; Roch K. Dabiré; Carole Else Eboumbou Moukoko; Jean Bosco Ouédraogo; Yap Boum II; John Shon; Daouda Ndiaye; Adam Wisnewski; Sunil Parikh; Akiko Iwasaki; Craig B. Wilen; Albert I. Ko; Aaron M. Ring; Amy K. Bei.
Afiliação
  • Sarah Lapidus; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA
  • Feimei Liu; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA
  • Arnau Casanovas-Massana; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA
  • Yile Dai; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA
  • John D. Huck; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA
  • Carolina Lucas; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA
  • Jon Klein; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA
  • Renata B. Filler; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA, Yale School of Medicine, Department of Laboratory Medicine, New Haven, CT, 0651
  • Madison S. Strine; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA, Yale School of Medicine, Department of Laboratory Medicine, New Haven, CT, 0651
  • Mouhamad Sy; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal
  • Awa B. Deme; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal
  • Aida S. Badiane; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal
  • Baba Dieye; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal
  • Ibrahima Mbaye Ndiaye; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal
  • Younous Diedhiou; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal
  • Amadou Moctar Mbaye; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal
  • Cheikh Tidiane Diagne; DiaTROPIX Rapid Diagnostic Tests Facility, Institut Pasteur de Dakar, Dakar, Senegal
  • Inés Vigan-Womas; Department of Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal
  • Alassane Mbengue; G4 - Malaria Experimental Genetic Approaches and Vaccines, Department of Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Sen
  • Bacary D. Sadio; Department of Virologie, Institut Pasteur de Dakar, Dakar, Senegal
  • Moussa M. Diagne; Department of Virologie, Institut Pasteur de Dakar, Dakar, Senegal
  • Adam J. Moore; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA
  • Khadidiatou Mangou; G4 - Malaria Experimental Genetic Approaches and Vaccines, Department of Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Sen
  • Fatoumata Diallo; G4 - Malaria Experimental Genetic Approaches and Vaccines, Department of Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Sen
  • Seynabou D. Sene; G4 - Malaria Experimental Genetic Approaches and Vaccines, Department of Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Sen
  • Mariama N. Pouye; G4 - Malaria Experimental Genetic Approaches and Vaccines, Department of Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Sen
  • Rokhaya Faye; Department of Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal
  • Babacar Diouf; Department of Immunophysiopathologie et Maladies Infectieuses, Institut Pasteur de Dakar, Dakar, Senegal
  • Nivison Nery Jr; Instituto de Saúde Coletiva, Universidade Federal da Bahia, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, BA, Brazil
  • Federico Costa; Instituto de Saúde Coletiva, Universidade Federal da Bahia, Instituto de Saúde Coletiva, Universidade Federal da Bahia, Instituto Gonçalo Moniz, Fundação Oswald
  • Mitermayer Reis; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, BA, Brazil
  • M. Catherine Muenker; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA
  • Daniel Z. Hodson; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA
  • Yannick Mbarga; Douala Military Hospital, Douala, Cameroon
  • Ben Z. Katz; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Division of Infectious Diseases, Ann and Robert H. Lurie Children's Hospital of C
  • Jason R. Andrews; Division of Infectious Diseases and Geographic Medicine, School of Medicine, Stanford University, Stanford, CA, USA
  • Melissa Campbell; Yale Center for Clinical Investigation, Yale School of Medicine, New Haven, Connecticut, USA
  • Ariktha Srivathsan; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA
  • Kathy Kamath; Serimmune, Inc, Goleta, CA
  • Elisabeth Baum-Jones; Serimmune, Inc, Goleta, CA
  • Ousmane Faye; Department of Virologie, Institut Pasteur de Dakar, Dakar, Senegal
  • Amadou Alpha Sall; Department of Virologie, Institut Pasteur de Dakar, Dakar, Senegal
  • Juan Carlos Quintero Vélez; Grupo de Investigación Ciencias Veterinarias Centauro, Grupo de Investigación Ciencias Veterinarias Centauro, Grupo de Investigación Microbiología Básica y Apli
  • Michael Cappello; Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA
  • Michael Wilson; Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana
  • Choukri Ben-Mamoun; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA
  • Fabrice A. Somé; Institut de Recherche en Sciences de La Santé (IRSS)/Centre Muraz, Bobo-Dioulasso, Burkina Faso
  • Roch K. Dabiré; Institut de Recherche en Sciences de La Santé (IRSS)/Centre Muraz, Bobo-Dioulasso, Burkina Faso
  • Carole Else Eboumbou Moukoko; Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon, Malaria Research Unit, Center Pasteu
  • Jean Bosco Ouédraogo; Institut de Recherche en Sciences de La Santé (IRSS)/Centre Muraz, Bobo-Dioulasso, Burkina Faso
  • Yap Boum II; University of Yaoundé and Epicentre, Médecins Sans Frontières
  • John Shon; Serimmune, Inc., Goleta, CA
  • Daouda Ndiaye; Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology, Dakar, Senegal
  • Adam Wisnewski; Yale Occupational and Environmental Medicine Program, Department of Internal Medicine, Yale School of Medicine
  • Sunil Parikh; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA
  • Akiko Iwasaki; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA
  • Craig B. Wilen; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA
  • Albert I. Ko; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, 06510, USA, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Minis
  • Aaron M. Ring; Yale School of Medicine, Department of Immunobiology, New Haven, CT, 06510, USA
  • Amy K. Bei; Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, USA, Cheikh Anta Diop University, Aristide le Dantec Hospital, Dakar
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21256855
ABSTRACT
Individuals with acute malaria infection generated high levels of antibodies that cross-react with the SARS-CoV-2 Spike protein. Cross-reactive antibodies specifically recognized the sialic acid moiety on N-linked glycans of the Spike protein and do not neutralize in vitro SARS-CoV-2. Sero-surveillance is critical for monitoring and projecting disease burden and risk during the pandemic; however, routine use of Spike protein-based assays may overestimate SARS-CoV-2 exposure and population-level immunity in malaria-endemic countries.
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Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Prognostic_studies / Rct Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Prognostic_studies / Rct Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint