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SARS-CoV-2 under an elimination strategy in Hong Kong
Haogao Gu; Ruopeng Xie; Dillon C. Adam; Joseph L.-H. Tsui; Daniel K. Chu; Lydia D.J. Chang; Sammi S.Y. Cheuk; Shreya Gurung; Pavithra Krishnan; Daisy Y.M. Ng; Gigi Y.Z. Liu; Carrie K.C. Wan; Kimberly M. Edwards; Kathy S.M. Leung; Joseph T. Wu; Dominic N.C. Tsang; Gabriel M. Leung; Benjamin J. Cowling; Malik Peiris; Tommy T.Y. Lam; Vijaykrishna Dhanasekaran; Leo Poon.
Afiliação
  • Haogao Gu; The University of Hong Kong
  • Ruopeng Xie; The University of Hong Kong
  • Dillon C. Adam; The University of Hong Kong
  • Joseph L.-H. Tsui; The University of Hong Kong
  • Daniel K. Chu; The University of Hong Kong
  • Lydia D.J. Chang; The University of Hong Kong
  • Sammi S.Y. Cheuk; The University of Hong Kong
  • Shreya Gurung; The University of Hong Kong
  • Pavithra Krishnan; The University of Hong Kong
  • Daisy Y.M. Ng; The University of Hong Kong
  • Gigi Y.Z. Liu; The University of Hong Kong
  • Carrie K.C. Wan; The University of Hong Kong
  • Kimberly M. Edwards; The University of Hong Kong
  • Kathy S.M. Leung; The University of Hong Kong
  • Joseph T. Wu; The University of Hong Kong
  • Dominic N.C. Tsang; Department of Health, The Government of Hong Kong Special Administrative Region
  • Gabriel M. Leung; The University of Hong Kong
  • Benjamin J. Cowling; The University of Hong Kong
  • Malik Peiris; The University of Hong Kong
  • Tommy T.Y. Lam; The University of Hong Kong
  • Vijaykrishna Dhanasekaran; The University of Hong Kong
  • Leo Poon; The University of Hong Kong
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21259169
ABSTRACT
Hong Kong utilized an elimination strategy with intermittent use of public health and social measures and increasingly stringent travel regulations to control SARS-CoV-2 transmission. By analyzing >1700 genome sequences representing 17% of confirmed cases from 23-January-2020 to 26-January-2021, we reveal the effects of fluctuating control measures on the evolution and epidemiology of SARS-CoV-2 lineages in Hong Kong. Despite numerous importations, only three introductions were responsible for 90% of locally-acquired cases, two of which circulated cryptically for weeks while less stringent measures were in place. We found that SARS-CoV-2 within-host diversity was most similar among transmission pairs and epidemiological clusters due to a strong transmission bottleneck through which similar genetic background generates similar within-host diversity. One sentence summaryOut of the 170 detected introductions of SARS-CoV-2 in Hong Kong during 2020, three introductions caused 90% of community cases.
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Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Observational_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Observational_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint