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Plasma cell-free DNA promise disease monitoring and tissue injury assessment of COVID-19
Xin Jin; Yanqun Wang; Jinjin Xu; Yimin Li; Fanjun Cheng; Yuxue Luo; Haibo Zhou; Shanwen Lin; Fei Xiao; Lu Zhang; Yu Lin; Zhaoyong Zhang; Yan Jin; Fang Zheng; Wei Chen; Airu Zhu; Ye Tao; Jingxian Zhao; Tingyou Kuo; Yuming Li; Lingguo Li; Liyan Wen; Rijing Ou; Fang Li; Long Lin; Yanjun Zhang; Jing Sun; Hao Yuan; Zhen Zhuang; Haixi Sun; Zhao Chen; Jie Li; Jianfen Zhuo; Dongsheng Chen; Shengnan Zhang; Yuzhe Sun; Peilan Wei; Jinwei Yuan; Tian Xu; Huanming Yang; Jian Wang; Xun Xu; Nanshan Zhong; Yonghao Xu; Kun Sun; Jincun Zhao.
Afiliação
  • Xin Jin; BGI-Shenzhen
  • Yanqun Wang; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Jinjin Xu; BGI-Shenzhen
  • Yimin Li; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Fanjun Cheng; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • Yuxue Luo; BGI-Shenzhen
  • Haibo Zhou; The Sixth Affiliated Hospital of Guangzhou Medical University
  • Shanwen Lin; Yangjiang People Hospital
  • Fei Xiao; Department of Infectious Diseases, Guangdong Provincial Key Laboratory of Biomedical Imaging, Guangdong Provincial Engineering Research Center of Molecular Imag
  • Lu Zhang; Institute of Infectious disease, Guangzhou Eighth People's Hospital of Guangzhou Medical University
  • Yu Lin; BGI-Shenzhen
  • Zhaoyong Zhang; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Yan Jin; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • Fang Zheng; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
  • Wei Chen; School of Medicine, South China University of Technology
  • Airu Zhu; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Ye Tao; BGI-Shenzhen
  • Jingxian Zhao; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Tingyou Kuo; BGI-Shenzhen
  • Yuming Li; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Lingguo Li; BGI-Shenzhen
  • Liyan Wen; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Rijing Ou; BGI-Shenzhen
  • Fang Li; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Long Lin; BGI-Shenzhen
  • Yanjun Zhang; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Jing Sun; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Hao Yuan; BGI-Shenzhen
  • Zhen Zhuang; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Haixi Sun; BGI-Shenzhen
  • Zhao Chen; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Jie Li; BGI-Shenzhen
  • Jianfen Zhuo; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Dongsheng Chen; BGI-Shenzhen
  • Shengnan Zhang; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Yuzhe Sun; BGI-Shenzhen
  • Peilan Wei; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Jinwei Yuan; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Tian Xu; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Huanming Yang; BGI-Shenzhen
  • Jian Wang; BGI-Shenzhen
  • Xun Xu; BGI-Shenzhen
  • Nanshan Zhong; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Yonghao Xu; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
  • Kun Sun; Shenzhen Bay Laboratory
  • Jincun Zhao; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Aff
Preprint em Inglês | medRxiv | ID: ppmedrxiv-21260139
ABSTRACT
COVID-19 is a huge threat to global health. Due to the lack of definitive etiological therapeutics currently, effective disease monitoring is of high clinical value for better healthcare and management of the large number of COVID-19 patients. In this study, we recruited 37 COVID-19 patients, collected 176 blood samples upon diagnosis and during treatment, and analyzed cell-free DNA (cfDNA) in these samples. We report gross abnormalities in cfDNA of COVID-19 patients, including elevated GC content, altered molecule size and end motif patterns. More importantly, such cfDNA characteristics reflect patient-specific physiological conditions during treatment. Further analysis on tissue origin tracing of cfDNA reveals frequent tissue injuries in COVID-19 patients, which is supported by clinical diagnoses. Hence, we demonstrate the translational merit of cfDNA as valuable analyte for effective disease monitoring, as well as tissue injury assessment in COVID-19 patients.
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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo de etiologia / Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo de etiologia / Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint