Your browser doesn't support javascript.
loading
COVID-19 Vaccine Efficacy in a Diverse Urban Healthcare Worker Population
Eirini Iliaki; Fan-Yun Lan; Costas A. Christophi; Guido Guidotti; Alexander D. Jobrack; Jane Buley; Neetha Nathan; Rebecca Osgood; Lou Ann Bruno-Murtha; Stefanos N. Kales.
Afiliação
  • Eirini Iliaki; Occupational Medicine, Cambridge Health Alliance, Harvard Medical School, Cambridge MA, USA
  • Fan-Yun Lan; Occupational Medicine, Cambridge Health Alliance, Harvard Medical School, Cambridge MA, USA
  • Costas A. Christophi; Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus
  • Guido Guidotti; Department of Environmental Health, Harvard University T.H. Chan School of Public Health, Boston, MA, USA
  • Alexander D. Jobrack; Department of Environmental Health, Harvard University T.H. Chan School of Public Health, Boston, MA, USA
  • Jane Buley; Occupational Medicine, Cambridge Health Alliance, Harvard Medical School, Cambridge MA, USA
  • Neetha Nathan; Occupational Medicine, Cambridge Health Alliance, Harvard Medical School, Cambridge MA, USA
  • Rebecca Osgood; Pathology, Cambridge Health Alliance, Harvard Medical School, Cambridge MA, USA
  • Lou Ann Bruno-Murtha; Infection Prevention and Infectious Diseases, Cambridge Health Alliance, Harvard Medical School, Cambridge MA, USA
  • Stefanos N. Kales; Occupational Medicine, Cambridge Health Alliance, Harvard Medical School, Cambridge MA, USA
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21263038
ABSTRACT
ObjectiveTo investigate COVID-19 vaccine efficacy (VE) among healthcare workers (HCWs) in an ethnically diverse community healthcare system, during its initial immunization campaign. MethodsHCWs of the system were retrospectively included from the beginning of a COVID-19 vaccination program (December 16, 2020) until March 31, 2021. Those with a prior COVID-19 infection before December 15 were excluded. The Occupational Health department of the system ran a COVID-19 screening and testing referral program for workers, consistently throughout the study period. A master database had been established and updated comprising of the demographics, COVID-19 PCR assays, and vaccinations of each HCW. Andersen-Gill extension of the Cox models were built to estimate the VE of fully/partially vaccinated person-days at risk. ResultsAmong the 4317 eligible HCWs, 3249 (75%) received any vaccination during the study period. Vaccinated HCWs were older, less likely to be Black/African American, Hispanic/Latino or identify as two or more races, and more likely to be medical providers. After adjusting for age, sex, race, and the statewide background incidence at the time of vaccination, we observed a VE of 80.2% (95% CI 57.5-90.8%) for [greater double equals]14 days after the first dose of Pfizer/Moderna, and 95.5% (95% CI 88.2-98.3%) among those fully vaccinated (i.e. [greater double equals]14 days after the second dose of Pfizer/Moderna or the single dose of J&J/Janssen). ConclusionCOVID-19 vaccine effectiveness in the real world is promising, and these data in concert with culturally appropriate may decrease vaccine hesitancy.
Licença
cc_by_nd
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint