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Continued Effectiveness of COVID-19 Vaccination among Urban Healthcare Workers during Delta Variant Predominance
Fan-Yun Lan; Amalia Sidossis; Eirini Iliaki; Jane Buley; Neetha Nathan; Lou Ann Bruno-Murtha; Stefanos N. Kales.
Afiliação
  • Fan-Yun Lan; Cambridge Health Alliance, Harvard Medical School
  • Amalia Sidossis; Cambridge Health Alliance, Harvard Medical School
  • Eirini Iliaki; Cambridge Health Alliance, Harvard Medical School
  • Jane Buley; Cambridge Health Alliance, Harvard Medical School
  • Neetha Nathan; Cambridge Health Alliance, Harvard Medical School
  • Lou Ann Bruno-Murtha; Cambridge Health Alliance, Harvard Medical School
  • Stefanos N. Kales; Cambridge Health Alliance, Harvard Medical School
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21265753
ABSTRACT
BackgroundData on COVID-19 vaccine effectiveness (VE) among healthcare workers (HCWs) during periods of delta variant predominance are limited. MethodsWe followed a population of urban Massachusetts HCWs (45% non-White) subject to epidemiologic surveillance. We accounted for covariates such as demographics and community background infection incidence, as well as information bias regarding COVID-19 diagnosis and vaccination status. Results and DiscussionDuring the study period (December 16, 2020 to September 30, 2021), 4615 HCWs contributed to a total of 1,152,486 person-days at risk (excluding 309 HCWs with prior infection) and had a COVID-19 incidence rate of 5.2/10,000 (114 infections out of 219,842 person-days) for unvaccinated person-days and 0.6/10,000 (49 infections out of 830,084 person-days) for fully vaccinated person-days, resulting in an adjusted VE of 82.3% (95% CI 75.1-87.4%). For the secondary analysis limited to the period of delta variant predominance in Massachusetts (i.e., July 1 to September 30, 2021), we observed an adjusted VE of 76.5% (95% CI 40.9-90.6%). Independently, we found no re-infection among those with prior COVID-19, contributing to 74,557 re-infection-free person-days, adding to the evidence base for the robustness of naturally acquired immunity.
Licença
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Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Experimental_studies / Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Experimental_studies / Observational_studies / Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint