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Comparison of the Immunogenicity of five COVID-19 vaccines in Sri Lanka
Chandima Jeewandara; Inoka Aberathna; Saubhagya Danasekara; Laksiri Gomes; Suranga Fernando; Dinuka Guruge; Thushali Ranasinghe; Banuri Gunasekara; Achala Kamaladasa; Heshan Kuruppu; Gayasha Somathilaka; Jeewantha Jayamali; Deshni Jayathilaka; Helanka Wijayathilake; Pradeep Pushpakumara; Michael Harvie; Thashmi Nimasha; Shiromi de Silva; Ruwan Wijayamuni; Lisa Schimanski; Pramila Rijal; Jack Tan; Alain Townsend; Graham Ogg; Gathsaurie Neelika Malavige.
Afiliação
  • Chandima Jeewandara; University of Sri Jayewardenepura
  • Inoka Aberathna; University of Sri Jayewardenepura
  • Saubhagya Danasekara; University of Sri Jayewardenepura
  • Laksiri Gomes; University of Sri Jayewardenepura
  • Suranga Fernando; Ministry of Health, Sri Lanka
  • Dinuka Guruge; Colombo Municipal Council, Colombo, Sri Lanka.
  • Thushali Ranasinghe; University of Sri Jayewardenepura
  • Banuri Gunasekara; University of Sri Jayewardenepura
  • Achala Kamaladasa; University of Sri Jayewardenepura
  • Heshan Kuruppu; University of Sri Jayewardenepura
  • Gayasha Somathilaka; University of Sri Jayewardenepura
  • Jeewantha Jayamali; University of Sri Jayewardenepura
  • Deshni Jayathilaka; University of Sri Jayewardenepura
  • Helanka Wijayathilake; Ministry of Health, Sri Lanka
  • Pradeep Pushpakumara; University of Sri Jayewardenepura
  • Michael Harvie; University of Sri Jayewardenepura
  • Thashmi Nimasha; University of Sri Jayewardenepura
  • Shiromi de Silva; Colombo Municipal Council, Colombo, Sri Lanka
  • Ruwan Wijayamuni; Colombo Municipal Council, Colombo, Sri Lanka.
  • Lisa Schimanski; Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK."
  • Pramila Rijal; Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.
  • Jack Tan; Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.
  • Alain Townsend; University of Oxford
  • Graham Ogg; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
  • Gathsaurie Neelika Malavige; University of Sri Jayewardenepura
Preprint em Inglês | medRxiv | ID: ppmedrxiv-21267834
ABSTRACT
We assessed antibody responses 3 months post-vaccination in those who received mRNA-1273 (n=225), Sputnik V (n=128) or the first dose of Gam-COVID-Vac (n=184) and compared the results with previously reported data of Sinopharm and AZD1222 vaccinees. 99.5% of Moderna >94% of AZD1222 or Sputnik V, 72% to 76% of Gam-COVID-Vac (first dose) and 38.1% to 68.3% of Sinopharm vaccinees had ACE2 blocking antibodies above the positive threshold. The ACE2 blocking antibody levels were highest to lowest was Moderna > Sputnik V/ AZD1222 (had equal levels)> first dose of Gam-COVID-Vac > Sinopharm. All Moderna recipients had antibodies above the positive threshold to the ancestral (WT), B.1.1.7, B.1.351.1 and 80% positivity rate for B.1.617.2. Positivity rates of Sputnik V vaccinees for WT and variants, were higher than AZD1222 vaccinees, while Sinopharm vaccinees had the lowest positivity rates (<16.7%). These findings highlight the need for further studies to understand the effects on clinical outcomes.
Licença
cc_by_nc_nd
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
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