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A scoping review of regulatory T cell dynamics in convalescent COVID-19 patients - Implications for Long COVID?
Simon Haunhorst; Wilhelm Bloch; Florian Javelle; Karsten Krueger; Sabine Baumgart; Sebastian Drube; Christina Lemhoefer; Philipp Reuken; Andreas Stallmach; Michael Mueller; Christina E. Zielinski; Mathias W. Pletz; Holger H.W. Gabriel; Christian Puta.
Afiliação
  • Simon Haunhorst; Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Jena, Germany
  • Wilhelm Bloch; Department for Molecular and Cellular Sports Medicine, Institute for Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germ
  • Florian Javelle; Department for Molecular and Cellular Sports Medicine, Institute for Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germ
  • Karsten Krueger; Department of Exercise Physiology and Sports Therapy, Institute of Sports Science, Justus-Liebig-University Giessen, Giessen, Germany
  • Sabine Baumgart; Institute for Immunology, Jena University Hospital, Jena, Germany
  • Sebastian Drube; Institute for Immunology, Jena University Hospital, Jena, Germany
  • Christina Lemhoefer; Institute of Physiotherapy, Jena University Hospital, Jena, Germany
  • Philipp Reuken; Clinic for Internal Medicine IV (Gastroenterology, Hepatology and Infectious Diseases), Jena University Hospital, Jena, Germany
  • Andreas Stallmach; Clinic for Internal Medicine IV (Gastroenterology, Hepatology and Infectious Diseases), Jena University Hospital, Jena, Germany
  • Michael Mueller; Department of Infection Immunology, Leibniz Institute for Natural Product Research and Infection Immunology, Hans Knoell Institute, Jena, Germany
  • Christina E. Zielinski; Department of Infection Immunology, Leibniz Institute for Natural Product Research and Infection Immunology, Hans Knoell Institute, Jena, Germany
  • Mathias W. Pletz; Institute for Immunology, Jena University Hospital, Jena, Germany; Institute for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germ
  • Holger H.W. Gabriel; Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Jena, Germany
  • Christian Puta; Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Jena, Germany
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-22280642
ABSTRACT
BackgroundRecovery from coronavirus disease 2019 (COVID-19) can be impaired by the persistence of symptoms or new-onset health complications, commonly referred to as Long COVID. In a subset of patients, Long COVID is associated with immune system perturbations of unknown etiology, which could be related to compromised immunoregulatory mechanisms. ObjectiveThe aim of this scoping review was to investigate if regulatory T cell (Treg) dysregulation is observable beyond the acute illness and if it might be involved in Long COVID immunopathology. DesignA systematic search of studies investigating Tregs during COVID-19 convalescence was conducted on MEDLINE (via Pubmed) and Web of Science. ResultsThe literature search yielded 17 relevant studies, of which three included a distinct cohort of patients with Long COVID. The reviewed studies suggest that the Treg population of COVID-19 patients can reconstitute quantitatively and functionally during recovery. However, the comparison between recovered and seronegative controls revealed that an infection-induced dysregulation of the Treg compartment can be sustained for at least several months. The small number of studies investigating Tregs in Long COVID allowed no firm conclusions to be drawn about their involvement in the syndromes etiology. Yet, even almost one year post-infection Long COVID patients exhibit significantly altered proportions of Tregs within the CD4+ T cell population. ConclusionsPersistent alterations in cell frequency in Long COVID patients indicate that Treg dysregulation might be linked to immune system-associated sequelae. Future studies should aim to address the association of Treg adaptations with different symptom clusters and blood parameters beyond the sole quantification of cell frequencies while adhering to consensualized phenotyping strategies.
Licença
cc_by_nc
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Cohort_studies / Etiology_studies / Observational_studies / Prognostic_studies / Review / Systematic_reviews Idioma: En Ano de publicação: 2022 Tipo de documento: Preprint
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Cohort_studies / Etiology_studies / Observational_studies / Prognostic_studies / Review / Systematic_reviews Idioma: En Ano de publicação: 2022 Tipo de documento: Preprint