EXPRESSION OF P53 IN COLORECTAL CARCINOMAS AND ITS CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS

ABSTRACT

Colorectal cancer is one of the most life-threatening gastrointestinal diseases encountered in clinical practice.1 The rectum is one of the most frequently involved sites and accounts for 25% of primary colorectal cancers.2 Accumulation of molecular alterations, including K-ras, P53, Bcl-2 and adenomatous polyposis coli, contribute to colorectal carcinogenesis.3 According to the literature, the deletion of p53 with the overexpression of p53 protein is correlated with a low rate of survival, thus being an independent prognosis factor.17 Summary: Overexpression of p53 protein is associated with high grade of colorectal carcinoma