Molecular studies on Yemeni sickle-cell-disease patients: Xmn I polymorphism
(East. Mediterr. health j).
em Inglês
| WHO IRIS
| ID: who-118815
Biblioteca responsável:
CH1.1
ABSTRACT
Our studies of the Saudi population have shown that in patients with mild presentation of sickle-cell disease [SCD] from Saudi Arabia's eastern region, the prevalence of polymorphic sites is high. However, the prevalence is very low in patients with severe SCD from the south-west of the country. We expanded these studies to a group of Yemeni patients with severe SCD, resident in Riyadh. We investigated a total of 60 chromosomes carrying the sickle-cell [Hb S] gene and 14 chromosomes carrying the Hb A gene. Amongst the Hb AA group, the prevalence was 42.9% and 57.1% for the presence [+] and absence [-] of Xmn I polymorphic sites. In the Hb SS individuals, the prevalence of Xmn I polymorphic sites was similar to the prevalence reported in the south-western region of Saudi Arabia
Texto completo:
Disponível
Coleções:
Bases de dados de organismos internacionais
Base de dados:
WHO IRIS
Assunto principal:
Polimorfismo Genético
/
Índice de Gravidade de Doença
/
Globinas
/
Hemoglobina A
/
Hemoglobina Falciforme
/
Desoxirribonucleases de Sítio Específico do Tipo II
/
Estudos de Casos e Controles
/
Contagem de Eritrócitos
/
Índices de Eritrócitos
/
Anemia Falciforme
Idioma:
Inglês
Revista:
East. Mediterr. health j
Ano de publicação:
1999