Design, synthesis and biological evaluation of 8-hydroxyquinoline derivatives as potential clostridium difficile antibiotics / 药学实践与服务
Journal of Pharmaceutical Practice and Service
; (12): 737-740, 2023.
Article
em Zh
| WPRIM
| ID: wpr-1003620
Biblioteca responsável:
WPRO
ABSTRACT
Objective To find a more effective alternative therapy for antibiotic therapy and fecal microbiota transplantation in current primary treatment of clostridioides difficile infection (CDI) because of the high recurrence rate. Methods A series of 8-hydroxyquinoline derivatives were designed and synthesized based on 8-hydroxyquinoline scarffold. Results The activity test against C. difficile showed that most of the molecules exhibited good antibacterial activity against C. difficile, and compound 6f showed attractive anti-C. difficile activity. Conclusion A new type of 8-hydroxyquinoline derivatives with anti-clostridium difficile was found, which could be used as good lead compounds for further development.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Pharmaceutical Practice and Service
Ano de publicação:
2023
Tipo de documento:
Article