Advances in live-imaging aging reporter mice / 生理学报
Acta Physiologica Sinica
; (6): 836-846, 2023.
Article
em Zh
| WPRIM
| ID: wpr-1007794
Biblioteca responsável:
WPRO
ABSTRACT
Aging is an independent risk factor for chronic diseases in the elderly, and understanding aging mechanisms is one of the keys to achieve early prevention and effective intervention for the diseases. Aging process is dynamic and systemic, making it difficult for mechanistic study. With recent advances in aging biomarkers and development of live-imaging technologies, more and more reporter mouse models have been generated, which can live monitor the aging process, and help investigate aging mechanisms at systemic level and develop intervention strategies. This review summarizes recent advances in live-imaging aging reporter mouse models based on widely used aging biomarkers (p16Ink4a, p21Waf1/Cip1, p53 and Glb1), and discusses their applications in aging research.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Envelhecimento
/
Biomarcadores
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Proteína Supressora de Tumor p53
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Inibidor p16 de Quinase Dependente de Ciclina
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Inibidor de Quinase Dependente de Ciclina p21
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Ano de publicação:
2023
Tipo de documento:
Article