Mechanism of action and exogenous supplementation of vitamin D in Crohn's disease / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 870-876, 2023.
Article
em Zh
| WPRIM
| ID: wpr-1009834
Biblioteca responsável:
WPRO
ABSTRACT
Vitamin D can not only regulate calcium and phosphorus metabolism, but also exert an immunoregulatory effect. Vitamin D deficiency is common in patients with Crohn's disease (CD). Studies have shown that vitamin D is associated with CD and other autoimmune diseases and can improve the condition of patients with CD and promote their recovery by regulating intestinal immunity, repairing the intestinal mucosal barrier, inhibiting intestinal fibrosis, enhancing the response to infliximab, and regulating intestinal microbiota. Exogenous vitamin D supplementation can induce disease remission while increasing the serum level of vitamin D. However, only a few randomized, double-blind, and placebo-controlled trials have investigated the therapeutic effect of vitamin D in CD, and the optimal form of vitamin D supplementation, the specific dosage of vitamin D supplementation, and the optimal serum maintenance concentration of vitamin D remain to be clarified. This article mainly discusses the mechanism of action of vitamin D in CD and the beneficial effect of exogenous vitamin D supplementation on CD.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Vitamina D
/
Cálcio da Dieta
/
Doença de Crohn
/
Suplementos Nutricionais
/
Infliximab
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2023
Tipo de documento:
Article