W3D improves LPS-induced acute lung injury in mice by regulating TLR4/MD2-NF-κB p65 signaling pathway / 中国药理学通报

ABSTRACT

Aim To investigate the protective effect of new structure compound 4-(5'-dimethylamino)-naphthalenesulfonyl-2 (3H)-benzoxazolone (W3D) on lipopolysaccharide (LPS) induced acute lung injury (ALI) and the underlying mechanism. Methods ICR mice were randomly divided into control group, LPS model group, chlorzoxazone (12.5 mg · kg