Regulation of the Sigma-1 Receptor on Chronic Pain and Its Neuromechanism / 中国生物化学与分子生物学报

ABSTRACT

Sigma-1 receptor (Sig-1R) is a ligand-regulated chaperone protein widely expressed in multiple regions of the nervous system. It mediates intracellular effects of several types of ion channels and G protein coupled receptors (GPCRs) by binding them, and regulates intracellular Ca