Recent advances in drug screening methods of SARS-CoV-2 spike protein / 药学学报
Acta Pharmaceutica Sinica
; (12): 298-312, 2024.
Article
em Zh
| WPRIM
| ID: wpr-1016639
Biblioteca responsável:
WPRO
ABSTRACT
The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a serious impact on global public health and the economy. SARS-CoV-2 infiltrates host cells via its surface spike protein, which binds to angiotensin-converting enzyme 2 on the host cell membrane. As a result, small molecules targeting spike protein have emerged as a hotspot in anti-SARS-CoV-2 drug research. Activity screening is an important step in seeking small molecule drugs. Therefore, this article aims to review the biological activity evaluation methods of small molecule inhibitors targeting SARS-CoV-2 spike protein, with the goal of laying the foundation for the discovery of new anti-SARS-CoV-2 drugs.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2024
Tipo de documento:
Article