Advances in epithelial mesenchymal transition signaling in bronchopulmonary dysplasia / 国际儿科学杂志

ABSTRACT

With the rapid development of perinatal medical technology, the survival rate of preterm infants has increased significantly, but the incidence of bronchopulmonary dysplasia(BPD)is still at a high level.BPD is a common chronic respiratory disease in preterm infants, and the incidence of other complications and death rates of preterm infants with BPD are significantly higher.Currently, the "classic BPD" characterized by lung injury has been converted to "new BPD, " but the pathophysiological mechanism of BPD has not yet been elucidated.In recent years, some experimental studies in vitro and in vivo have demonstrated that alveolar type II epithelial cells can induce epithelial mesenchymal transition(EMT)through multiple signaling pathways, including TGF-β as a hub and Wnt, SPHK1/S1P, etc., which can promote the development of pulmonary fibrosis, and thus provide a new idea for the prevention and treatment of BPD.This article reviews the mechanisms of multiple signaling pathways in EMT in BPD, in order to give a reference for the clinical treatment of BPD.