Progress of N-myristoylation in oncology treatment / 肿瘤研究与临床

ABSTRACT

N-myristoylation is a type of protein modification and one of the most common types of protein lipidation. N-myristoylation affects cell signal transduction and metabolic pathway reprogramming by changing protein conformation, stability and localization. It is involved in various physiological and pathological processes. Studies have shown that the protein N-myristoyltransferase (NMT) is abnormally expressed in many types of malignancies and involves in development and progression of tumors. Inhibitors targeting NMT have good anticancer effects and provide potential targets for cancer recurrence and metastasis therapy. This article mainly introduces the protein N-myristoylation system and reviews its role and mechanism in the development and progression of tumors, summarizes the latest research progress of targeting protein N-myristoylation for the treatment of cancer in the last 5 years.