Correlation analysis between carotid elasticity transmission index and intima-media thickness of the carotid artery in patients with essential hypertension / 中华神经医学杂志

ABSTRACT

Objective To deduce carotid elasticity transmission index (CETI) and explore the correlation between CETI and intima-media thickness (IMT) of the carotid artery to investigate the clinical value of CETI. Methods Seventy-seven patients with essential hypertension (EH) and 24 healthy controls were collected. Their blood flow rate of cerebral arteries was detected by transcranial Doppler (TCD) and the pulsatility index (PI) was calculated. Their IMT and blood flow rate of common carotid artery (CCA) were detected by difunctional color Doppler; and then, their PI was calculated to analyze the correlation between CETI and IMT by curve fitting. The formulas were determined as CETI1=PIMCA/PICCA, CETI2=PHCA/PICCA and CETB=PIBA/PICCA. Multiple stepwise regression analysis was employed to reflect the sensitive factors of IMT and CETI. Results Curvilinear correlation (curve of quadratic equation) was noted between CETI, including CETI1, CETI2 and CETI3, and IMT; each of the determination coefficient was r2=0.665, 0.601 and 0.573, respectively. Quadratic equations were y1=0.504+0.049x+0.203x2, r=0.815, P=0.000; y2= 1.009-1.141x+0.891x2, r=0.775, P= 0.000; y3=0.775-0.687x+0.641x2, 7=0.756, P=0.000. Among them, the correlation between CETI1 and IMT was the most significant. Linear regression was noted between IMT and LDL-C, daily dosage of smoking, SBP and gender. Linear regression was noted between CETT1 and both SBP and daily dosage of smoking. Linear regression was noted between CETI1 and both SBP and daily dosage of smoking. Linear regression was noted between CETI3 and SBP, CHOL and daily dosage of smoking. Conclusions CETI increases with the increase of IMT, suggesting that the rate of cerebral atherosclerosis is faster than the one of carotid in hypertensive patients when the elastic reserve of intracranial carotid artery and cerebral arteries decreases and the thickness of IMT increases to a certain extent. The risk factors of CETI are similar to IMT.