Age, gender and history of diabetes influencing maximum standardized uptake value and standardized cerebral metabolic rate of glucose / 中华神经医学杂志

ABSTRACT

Objective To study the influence of age,gender and history of diabetes in maximum standardized uptake value (SUVmax) and standardized cerebral metabolic rate (SCMR) of glucose.Methods Seventy-nine healthy volunteers were recruited and evaluated by PET-CT examination.Region of interest (ROI) analysis was employed to measure the SUVmax in 13 ROIs of the brain and 13ROIs of the cerebellum.SCMR was amounted by left SUVmax/right SUVmax in the corresponding ROI point of each side in the same volunteer.The influences of age,gender and history of diabetes in SUVmax and SCMR were analyzed. Results No statistical significance of SUVmax was noted between the 2corresponding points in bilateral ROI (P＞0.05).Statistical significance of SUVmax was noted between each 2 points in the left and right ROI (leftF=14.280,rightF=14.680,P=0.000).Statistical difference of SUVmax was recorded in different age groups (P＜0.05).The female had significantly lower SUVmax in bilateral measurement points (2/26) as compared with the male (P＜0.05).Concerning the influence of history of diabetes,statistical significance of SUVmax was noted in almost all ROIs (18/26,P＜0.05).No statistical significance of SCMR in each ROI was noted in different groups of gender,age and diabetes (P＞0.05). Conclusion SCMRglu can eliminate the role of such influencing factors as age,gender and history of diabetes,which have been proved to exert some effect on the results of SUVmax; therefore,SCMRglu may provide a reliable indicator for further study.